From Default Mode Network to the Basal Configuration
Sex Differences in the Resting-State Brain Connectivity as a Function of Age and Their Clinical Correlates
Bibliographic Data
Connectomics is a framework that models brain structure and function interconnectivity as a network, rather than narrowly focusing on select regions-of-interest. MRI-derived connectomes can be structural, usually based on diffusion-weighted MR imaging, or functional, usually formed by examining fMRI blood-oxygen-level-dependent (BOLD) signal correlations. Recently, we developed a novel method for assessing the hierarchical modularity of functional brain networks-the probability associated community estimation (PACE). PACE uniquely permits a dual formulation, thus yielding equivalent connectome modular structure regardless of whether positive or negative edges are considered. This method was rigorously validated using the 1,000 functional connectomes project data set (F1000, RRID:SCR_005361) (1) and the Human Connectome Project (HCP, RRID:SCR_006942) (2, 3) and we reported novel sex differences in resting-state connectivity not previously reported. (4) This study further examines sex differences in regard to hierarchical modularity as a function of age and clinical correlates, with findings supporting a basal configuration framework as a more nuanced and dynamic way of conceptualizing the resting-state connectome that is modulated by both age and sex. Our results showed that differences in connectivity between men and women in the 22-25 age range were not significantly different. However, these same non-significant differences attained significance in both the 26-30 age group ( p = 0.003) and the 31-35 age group ( p basal configuration between sexes
Connectome · Connectomics · Default mode network · Functional connectivity · Functional magnetic resonance imaging · Human Connectome Project · Resting state fMRI · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Mental Health Research Topics · Neuroscience · Psychology
The cognitive control of emotion
Gender differences in depression
Cross-National Epidemiology of Major Depression and Bipolar Disorder
Resolution limit in community detection
Complex network measures of brain connectivity
Response styles and the duration of episodes of depressed mood.
Finding the Self? An Event-Related fMRI Study
Medial prefrontal cortex and self-referential mental activity
Fast unfolding of communities in large networks
| Citation velocity | historical |
|---|---|
| Highly cited | No |