Reducing Effect of Saikosaponin A, an Active Ingredient of Bupleurum falcatum, on Intake of Highly Palatable Food in a Rat Model of Overeating
Bibliographic Data
| ID | 15526280 |
|---|---|
| Authors | Paola Maccioni (0000-0001-9071-0636, National Research Council), Federica Fara (Neuroscience Institute), Gian Luigi Gessa (National Research Council), Mauro A M Carai (0000-0003-3526-6899, University of Cagliari), Young-Won Chin, Young‐Won Chin (0000-0001-6964-1779, Dongguk University), Jung Hwan Lee (Korea Institute of Science and Technology), Hak Cheol Kwon (0000-0002-4071-2331, Korea Institute of Science and Technology), Giancarlo Colombo (0000-0002-0194-8149, Neuroscience Institute, corresponding author) |
| Year | 2018 |
| Volume | 9 |
| Publication date | 2018-08-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00369 |
| OpenAlex | W2886765726 |
| Language | EN |
| References cited | 24 |
Recent lines of experimental evidence have indicated that saikosaponin A (SSA) – a bioactive ingredient of the medicinal plant, Bupleurum falcatum L. – potently and effectively reduced operant self-administration of chocolate and reinstatement of chocolate-seeking behavior in rats. The present study was designed to assess whether the protective properties of SSA on addictive-like, food-related behaviors generalize to a rat model of overeating of palatable food. To this end, rats were habituated to feed on a standard rat chow for 3 hours/day; every 4 days, the 3-hour chow-feeding session was followed by a 1-hour availability of highly palatable, calorie-rich Danish butter cookies or Oreo chocolate cookies. Even though fed, rats consumed large amounts of cookies; intake of calories from cookies (consumed in one hour) was even larger than that of calories from chow (consumed in 3 hours). SSA (0, 0.25, 0.5, and 1 mg/kg, i.p.) was administered 10 min before cookie presentation. Treatment with SSA resulted in a dose-related decrease in intake of both butter and chocolate cookies. Administration of the cannabinoid CB1 receptor antagonist/inverse agonist, rimonabant (0, 0.3, 1, and 3 mg/kg, i.p.; tested as reference compound), produced a similar reduction in intake of butter cookies. These results (a) contribute to the set-up and validation of a rat model of overeating, characterized by the intake of large amounts of unnecessary calories and (b) provide an additional piece of evidence to the anorectic profile of SSA in rats
Animal science · Anorectic · Antagonist · Appetite · Biology · Calorie · Cannabinoid receptor · Food intake · Ingredient · Obesity · Overeating · Receptor · Rimonabant · Self-administration · Biochemical Analysis and Sensing Techniques · Chemistry · Medicine · Natural product bioactivities and synthesis · Pharmacological Effects of Natural Compounds · Endocrinology · Food Science · Internal Medicine · Pharmacology
| Highly cited | No |
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