Lithium management of periodic mood fluctuations in behavioural frontotemporal dementia
A case report
Bibliographic Data
| ID | 15526560 |
|---|---|
| Authors | Vicent Llorca-Bofí (0000-0001-8467-1335, Hospital Universitari de Santa Maria), Iolanda Batalla (0000-0003-2652-8463, Universitat de Lleida, corresponding author), Maria Ruiz-Julián (Hospital Universitari de Santa Maria), Marina Adrados-Pérez (0000-0002-2924-0396, Hospital Universitari de Santa Maria), Esther Buil-Reiné (0000-0003-1688-8596, Hospital Universitari de Santa Maria), Gerard Piñol‐Ripoll (0000-0002-4495-2113, Instituto de Investigación Biomédica de Lleida), Xavier Gallart‐Palau (0000-0001-5160-8794, Valencian International University), Aurora Torrent (Hospital Universitari de Santa Maria) |
| Year | 2024 |
| Volume | 14 |
| Pages | 1325145-1325145 |
| Publication date | 2024-01-08 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2023.1325145 |
| PMID | 38264640 |
| OpenAlex | W4390666575 |
| Language | EN |
| References cited | 2 |
The behavioural variant of Frontotemporal Dementia (bvFTD) is a neurodegenerative condition characterized by behavioural and cognitive symptoms. Mood disturbances, including manic-like episodes, can occur in bvFTD, posing diagnostic and therapeutic challenges. This case report presents a 62-year-old male with bvFTD exhibiting weekly mood fluctuations alternating between manic and depressive-like states. While initial treatment with quetiapine and trazodone showed partial improvement, the periodicity of mood fluctuations persisted. Subsequently, lithium was introduced, resulting in a notable reduction in symptom severity for both manic and depressive episodes. This report highlights the potential use of lithium as a mood stabilizer in bvFTD patients with periodic mood fluctuations, refractory to standard treatments. Further research is needed to elucidate the mechanisms underlying lithium's efficacy in bvFTD and to establish treatment guidelines
Antidepressant · Anxiety · Bipolar disorder · Cognition · Dementia · Depressive symptoms · Frontotemporal dementia · Lithium (medication · Mood · Mood stabilizer · Psychiatry · Quetiapine · Schizophrenia (object-oriented programming · Trazodone · Alzheimer's disease research and treatments · Amyotrophic Lateral Sclerosis Research · Bipolar Disorder and Treatment · Clinical Psychology · Medicine · Psychology · Internal Medicine
| Highly cited | No |
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