Bee venom-derived phospholipase A2 modulates microglial activity to promote antidepressant effects in a menopausal mouse model
Bibliographic Data
| ID | 15526671 |
|---|---|
| Authors | Minsook Ye (0000-0002-7918-7992, Kyung Hee University), Insop Shim (0000-0002-8014-9782, Kyung Hee University, corresponding author) |
| Year | 2025 |
| Volume | 16 |
| Pages | 1694735-1694735 |
| Publication date | 2025-11-12 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1694735 |
| PMID | 41311824 |
| OpenAlex | W4416135634 |
| Language | EN |
| References cited | 31 |
These results indicate that bvPLA2 exerts antidepressant-like effects in OVX-induced menopausal depression, potentially through the modulation of neuroinflammation and oxidative stress pathways
Antidepressant · Mechanism of Action · Neuroinflammation · Neuroprotection · Oxidative stress · Phospholipase A2 · Sickness behavior · Signal transduction · Acupuncture Treatment Research Studies · Healthcare and Venom Research · Pain Mechanisms and Treatments
| Citation velocity | historical |
|---|---|
| Highly cited | No |