Regulation of miRNA expression in the prefrontal cortex by fecal microbiota transplantation in anxiety-like mice
Bibliographic Data
| ID | 15526795 |
|---|---|
| Authors | Simin Chen (0009-0007-8712-7176, Beijing University of Chinese Medicine), Mengjia Li (0000-0002-0336-5166, Beijing University of Chinese Medicine), Changqing Tong (0009-0002-9587-2110, Beijing University of Chinese Medicine), Yanan Wang (0009-0004-4757-9563, Beijing University of Chinese Medicine), Jiahui He (0000-0003-1004-9679, Beijing University of Chinese Medicine), Qi Shao (0009-0009-0939-8573, Beijing University of Chinese Medicine), Yan Liu (0000-0002-1612-779X, Beijing University of Chinese Medicine, corresponding author), Ying Wu (0000-0002-0016-8052, Fourth Affiliated Hospital of Guangxi Medical University, corresponding author), Yuehan Song (Beijing University of Chinese Medicine, corresponding author) |
| Year | 2024 |
| Volume | 15 |
| Pages | 1323801-1323801 |
| Publication date | 2024-02-12 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2024.1323801 |
| PMID | 38410679 |
| OpenAlex | W4391750161 |
| Language | EN |
| References cited | 5 |
This study demonstrates that anxiety-like behavior induced by human FMT can be transmitted through gut microbiota and is associated with miRNA expression in the prefrontal cortex. It is inferred that the reduction of Akkermansia caused by FMT from GAD patients leads to the upregulation of mmu-miR-488-3p expression, resulting in the downregulation of its downstream target gene Creb1 and interference with its related signaling pathway. These findings highlight the gut microbiota's crucial role in the GAD pathophysiology
Anxiety · Biology · Cognition · Fecal bacteriotherapy · microRNA · Prefrontal cortex · Psychiatry · Clinical Psychology · Gastrointestinal motility and disorders · Gut microbiota and health · Medicine · Neuroscience · Psychology · Tryptophan and brain disorders · Genetics · Internal Medicine · Transplantation
| Citation velocity | historical |
|---|---|
| Highly cited | No |