Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients
Bibliographic Data
| ID | 15526996 |
|---|---|
| Authors | Yong Liu (0000-0001-6741-4863, Central South University, corresponding author), Huai Tao (Hunan University of Traditional Chinese Medicine), Xiudeng Yang (Shaoyang University), Kai Huang (0000-0002-0884-1715, Second Xiangya Hospital of Central South University), Xianghui Zhang (0000-0002-4173-9990, Second Xiangya Hospital of Central South University), Cunyan Li (Hunan Normal University) |
| Year | 2019 |
| Volume | 10 |
| Publication date | 2019-04-10 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00217 |
| OpenAlex | W2939691681 |
| Language | EN |
| Citations received | 2 |
| References cited | 44 |
Schizophrenia (SZ) is a debilitating and heterogeneous disease. We hypothesized that oxytocin (OXT) system, inflammation and one-carbon metabolism would have a link with SZ. In this study, serum OXT, OXT receptor (OXTR), interleukin-6 (IL-6), high sensitivity CRP (hsCRP) and homocysteine (Hcy) levels were measured in fifty-two first-episode schizophrenia (FES) patients and forty-one healthy controls (HC) from the Second Xiangya Hospital of Central South University. Meanwhile, the mRNA expressions of OXT and OXTR genes were determined by real-time quantitative PCR. Serum OXT and OXTR levels were significantly lower in FES patients (518.96 ± 22.22 and 174.60±17.11 pg/ml) than HC group (711.58 ± 40.57 and 252.15 ± 20.62 pg/ml). Serum IL-6 and hsCRP levels showed no difference between two groups (1.82 ± 0.30 vs 1.69 ± 0.36 pg/ml, 0.66 (0.22, 1.07) vs 0.31 (0.13, 0.91) mg/L), but serum Hcy levels were significantly higher in FES patients (20.18 ± 1.83 vs 15.24 ± 0.82 μmol/ml). The FES patients (0.27 ± 0.02 and 0.20 ± 0.02) have relatively higher mRNA expressions of OXT and OXTR genes than HC group (0.16 ± 0.01 and 0.14 ± 0.01). In summary, our results suggested the possible function of OXT system and Hcy in the pathogenesis of SZ
Homocysteine · Inflammation · Oxytocin · Oxytocin receptor · Pathogenesis · Psychiatry · Receptor · Schizophrenia (object-oriented programming · Medicine · Neuroendocrine regulation and behavior · Stress Responses and Cortisol · Tryptophan and brain disorders · Endocrinology · Internal Medicine
| Citations per year | 0.4 |
|---|---|
| Citation span | 2021 - 2022 (2) |
| Highly cited | No |