Personalizing esketamine treatment in TRD and TRBD

The role of mentalization, cognitive rigidity, psychache, and suicidality

Bibliographic Data

ID15527203
AuthorsMiriam Olivola (0000-0003-0914-0539, University of Pavia), Filippo Mazzoni (0000-0002-4114-6829, University of Pavia), Barbara Tarantino (0000-0001-6384-2561, University of Pavia), Alessandro Guffanti (University of Pavia), Matteo Marcatili (0000-0002-1436-1961, Istituti di Ricovero e Cura a Carattere Scientifico), Monica Macellaro (0000-0001-5522-5897, University of Milan), Nicolaja Girone (0000-0003-0761-2096, University of Milan), Vassilis Martiadis (0000-0002-3344-1000, ASL Roma), Fabiola Raffone (0000-0002-1818-4237, ASL Roma), Tiziano Prodi (University of Milan, corresponding author), Natascia Brondino (0000-0002-3128-1592, University of Pavia), Giovanni Martinotti (0000-0002-7292-2341, University of Chieti-Pescara), Massimo Clerici (0000-0001-8769-6474, Istituti di Ricovero e Cura a Carattere Scientifico), Roberta Anniverno (Azienda Socio Sanitaria Territoriale Lariana), Bernardo Dell’Osso (0000-0001-9370-5365, University of Milan)
Year2026
Volume16
Pages1736114-1736114
Publication date2026-01-22
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2025.1736114
PMID41659188
OpenAlexW7125435990
LanguageEN
Citations received1
References cited41

These findings highlight the importance of a personalized treatment approach in treatment- resistant depressive episode patients. Esketamine may be particularly beneficial in reducing cognitive rigidity, improving mentalization, and breaking the cognitive inflexibility that contributes to sustained negative depressive thinking patterns. Further research is needed to refine patient stratification and optimize treatment strategies for individuals with treatment-resistant depressive episode patients

Cognition · Cognitive bias · Depression (economics · Depressive symptoms · Major depressive disorder · Treatment-resistant depression · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Mental Health Research Topics · Treatment of Major Depression

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