China Multi-Center Preschool Autism Project (CMPAP)

Design and Methodologies to Identify Clinical Symptom Features and Biomarkers of Autism Spectrum Disorders

Bibliographic Data

ID15527348
AuthorsTing Yang (0009-0008-0157-6411, Children's Hospital of Chongqing Medical University), Jiang Zhu (0000-0002-7935-5263, Children's Hospital of Chongqing Medical University), Qiu Li (0000-0002-0864-4885, Chongqing Medical University), Li Chen (0000-0002-8432-3338, Children's Hospital of Chongqing Medical University), Lijie Wu (0000-0002-0631-5076, China Medical University), Li-Jie Wu, Feiyong Jia (0000-0002-8309-1395, First Hospital of Jilin University), Fei-Yong Jia, Yan Hao (0000-0001-8830-8189, Tongji Hospital), Xiaoyan Ke (0009-0007-7526-3875, Nanjing Brain Hospital), Xiao-Yan Ke, Mingji Yi (Qingdao University), Ming-Ji Yi, Chunhua Jin (0000-0003-1962-3497, Capital Institute of Pediatrics), Chun-Hua Jin, Jie Chen (0000-0002-9254-4413, Chongqing Medical University, corresponding author), Ting Yu Li (China International Science and Technology Cooperation, corresponding author)
Year2021
Volume11
Pages613519-613519
Publication date2021-02-09
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2020.613519
PMID33633597
OpenAlexW3126831230
LanguageEN
References cited30

Background: The etiology of autism spectrum disorder (ASD) has not yet been fully identified, but it seems to be triggered by complex genetic and environmental risk factors. Moreover, the tremendous etiological and clinical differences among individuals with ASD has had a major negative impact on early diagnosis and individualized treatment. Earlier diagnosis of precise clinical subtypes of ASD could lead to individualized treatment and a better prognosis. However, few large-scale epidemiological studies have explored precise clinical subtypes and clinically meaningful biomarkers, especially in China. Methods and Design: The China Multi-center Preschool Autism Project (CMPAP) includes nearly 3,000 children-1,469 individuals with ASD and 1,499 typically-developing (TD) controls-from 13 cities in China. Using a case-control design, each participant was comprehensively characterized in terms of feeding and disease history, maternal history, family history, clinical core symptoms, comorbidities, biochemical markers, genomics, urine/fecal metabonomics, and intestinal flora. In addition, data on environmental risk factors were obtained using interviews and electronic medical records. Conclusion: The study was designed to: (1) investigate age at diagnosis and treatment and family and social support for preschool children with ASD in China, (2) develop a more accurate clinical subtype and intervention system for the ICD-11, and (3) find the specific genes and environmental markers of different subtypes, which will help in the development of early diagnosis and individual intervention programs for preschool children with ASD. This study will provide the basis for improving national health policies for ASD in China

Autism · Autism spectrum disorder · Etiology · Family history · Intervention (counseling · Pathology · Psychiatry · Autism Spectrum Disorder Research · Child Development and Digital Technology · Child Nutrition and Feeding Issues · Clinical Psychology · Medicine · Epidemiology · Internal Medicine · Pediatrics

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