Deficits in odor discrimination versus odor identification in patients with schizophrenia and negative correlations with Gabaergic and DNA methyltransferase mRNAs in lymphocytes

Bibliographic Data

ID15527405
AuthorsRobert C Smith (0000-0002-4933-4162, Nathan Kline Institute for Psychiatric Research, corresponding author), Henry Sershen (0000-0002-7922-2217, Nathan Kline Institute for Psychiatric Research), Mary Youssef (Nathan Kline Institute for Psychiatric Research), Ábel Lajtha (Nathan Kline Institute for Psychiatric Research), Hua Jin (0000-0002-2176-7556, VA San Diego Healthcare System), Mumei Zhang (Columbia University), AnMei Chen (Columbia University), Alessandro Guidotti (0000-0003-4480-0010, University of Illinois Chicago), John M Davis (0000-0003-3963-1654, University of Illinois Chicago)
Year2023
Volume14
Pages1115399-1115399
Publication date2023-03-28
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2023.1115399
PMID37056402
OpenAlexW4361214274
LanguageEN
References cited41

Odor discrimination was a more powerful variable than odor identification in discriminating CSZ from controls and should be used more regularly as an odor measure in studies of schizophrenia. The substantive meaning of the negative correlations of odor discrimination and GABAergic mRNA variables in peripheral lymphocytes of CSZ needs more investigation and comparison with results in neural tissue

Biology · DNA methylation · GABAergic · Gene · Gene expression · Inhibitory postsynaptic potential · Logistic regression · Odor · Psychiatry · Psychosis · Schizophrenia (object-oriented programming · Biochemical Analysis and Sensing Techniques · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Neuroscience · Olfactory and Sensory Function Studies · Psychology · Genetics · Internal Medicine

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