Case report
Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes
Bibliographic Data
| ID | 15527480 |
|---|---|
| Authors | Johannes Hebebrand (0000-0001-5364-6073, University of Duisburg-Essen), Jochen Antel (0000-0002-7992-5684, University of Duisburg-Essen, corresponding author), Linda von Piechowski (University of Münster), Cordula Kiewert (University of Duisburg-Essen), Burkhard Stüve (University of Duisburg-Essen), Gertraud Gradl-Dietsch (0000-0003-3577-0227, University of Duisburg-Essen) |
| Year | 2023 |
| Volume | 14 |
| Pages | 1267495-1267495 |
| Publication date | 2023-11-09 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2023.1267495 |
| PMID | 38025476 |
| OpenAlex | W4388652044 |
| Language | EN |
| References cited | 43 |
A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME/CSF) is uncommon. A 17 years-old male adolescent with possible onset of ME/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight loss was twice treated off-label with metreleptin for 15 and 11 days, respectively. As in previous cases, eating disorder specific cognitions and mood improved. Interestingly, fatigue and post-exertional muscle pain (P-EMP) improved, too. We discuss potential mechanisms. Treatment with metreleptin may prove beneficial in AN and in ME/CSF associated with substantial weight loss
Anorexia · Anorexia nervosa · Chronic fatigue syndrome · Comorbidity · Eating disorders · Encephalomyelitis · Mood · Multiple sclerosis · Obesity · Psychiatry · Weight loss · Eating Disorders and Behaviors · Exercise and Physiological Responses · Fibromyalgia and Chronic Fatigue Syndrome Research · Medicine · Psychology · Internal Medicine · Pediatrics
| Highly cited | No |
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