Transcranial magnetic stimulation and intravenous ketamine combination therapy for treatment-resistant bipolar depression
A case report
Bibliographic Data
| ID | 15527635 |
|---|---|
| Authors | Laurent Elkrief (0000-0002-2260-4433, Université de Montréal), Olivier Payette (Centre Hospitalier de l’Université de Montréal), Jean-Nicolas Foucault (Centre Hospitalier de l’Université de Montréal), Christophe Longpré-Poirier (0000-0003-1527-0874, Centre Hospitalier de l’Université de Montréal), Maxime Richard (0000-0001-7620-3814, Université de Montréal), Véronique Desbeaumes Jodoin (0000-0001-9784-942X, Centre Hospitalier de l’Université de Montréal), Paul Lespérance (0000-0001-9280-7925, Université de Montréal), Jean‐Philippe Miron (0000-0002-5277-541X, Centre Hospitalier de l’Université de Montréal, corresponding author), Jean-Philippe Miron |
| Year | 2022 |
| Volume | 13 |
| Pages | 986378-986378 |
| Publication date | 2022-09-21 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.986378 |
| PMID | 36213934 |
| OpenAlex | W4296745040 |
| Language | EN |
| References cited | 31 |
About a third of patients suffering from major depression develop treatment-resistant depression (TRD). Although repetitive transcranial magnetic stimulation (rTMS) and intravenous ketamine have proven effective for the management of TRD, many patients remain refractory to treatment. We present the case of a patient suffering from bipolar TRD. The patient was referred to us after failure to respond to first-and second-line pharmacotherapy and psychotherapy. After minimal response to both rTMS and ketamine alone, we attempted a combination rTMS and ketamine protocol, which led to complete and sustained remission. Various comparable and complimentary mechanisms of antidepressant action of ketamine and rTMS are discussed, which support further study of this combination therapy. Future research should focus on the feasibility, tolerability, and efficacy of this novel approach
Adverse effect · Anesthesia · Antidepressant · Anxiety · Deep brain stimulation · Depression (economics · Electroconvulsive therapy · Ketamine · Pharmacotherapy · Psychiatry · Psychotherapist · Refractory (planetary science · Schizophrenia (object-oriented programming · Stimulation · Tolerability · Transcranial magnetic stimulation · Treatment-resistant depression · Electroconvulsive Therapy Studies · Medicine · Psychology · Transcranial Magnetic Stimulation Studies · Treatment of Major Depression · Internal Medicine · Pharmacology
Large-Scale Network Dysfunction in Major Depressive Disorder
Large-scale brain networks and psychopathology
Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps
A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression
The Antidepressant Effect of Ketamine Is Dampened by Concomitant Benzodiazepine Medication
| Citation velocity | historical |
|---|---|
| Highly cited | No |