Psychodynamic profiles of major depressive disorder and generalized anxiety disorder in China

Bibliographic Data

ID15527680
AuthorsJia Xu (0000-0003-1238-1317, Peking University, corresponding author), Yuxi Wang (0000-0002-9897-7316, Peking University), Yujia Peng (0000-0002-2453-6622, Beijing Institute for General Artificial Intelligence, corresponding author)
Year2024
Volume15
Pages1312980-1312980
Publication date2024-01-23
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2024.1312980
PMID38322139
OpenAlexW4391138435
LanguageEN
Citations received2
References cited44

Traditional clinical diagnoses relying on symptoms may overlook latent factors that illuminate mechanisms and potentially guide treatment. The Operationalized Psychodynamic Diagnosis (OPD) system may compensate for symptom-based diagnosis by measuring psychodynamic profiles underlying mental disorders through conflicts and structure axes. However, OPD has not been widely adopted in China, and it remains unclear whether OPD can be used as an effective approach to distinguish between depression and anxiety. The current study aims to adopt the OPD system to investigate the psychodynamic profiles of major depressive disorder (MDD) and generalized anxiety disorder (GAD) in China, targeting patients with "pure" symptoms without comorbidity. We recruited 42 MDD patients, 32 GAD patients, and 31 healthy controls (HC), and assessed their self-report depression and anxiety symptoms, along with their underlying psychodynamic profiles through OPD interviews. Overall, both MDD and GAD patients showed more prominent conflict issues and lower levels of structure than HC. The MDD and GAD groups yielded different conflict profiles and conflict processing modes when processing their second conflicts. Importantly, the multi-dimensional psychodynamic profiles achieved machine learning classification of clinical groups with an accuracy of 0.84, supporting successful distinction of MDD and GAD patients. In conclusion, the OPD demonstrated sensitivity in revealing distinct psychodynamic profiles underlying "pure" depression and anxiety clinical populations in China. This work calls for future incorporation of OPD as a tool to investigate psychodynamic formulations underlying mental disorders, compensating for traditional symptom-based diagnostic approaches to guide precise individualized interventions

Anxiety · Comorbidity · Depression (economics · Generalized anxiety disorder · Major depressive disorder · Mood · Psychiatry · Psychodynamic psychotherapy · Psychodynamics · Psychological intervention · Psychotherapist · Clinical Psychology · Functional Brain Connectivity Studies · Mental Health Research Topics · Psychology · Treatment of Major Depression

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