A brain imaging study of dopamine receptor D2 availability in cannabis dependent users after recovery from cannabis-induced psychosis
Bibliographic Data
| ID | 15527771 |
|---|---|
| Authors | Aviv Weinstein (0000-0002-9465-9943, Ariel University, corresponding author), Aviv M Weinstein |
| Year | 2023 |
| Volume | 14 |
| Pages | 1230760-1230760 |
| Publication date | 2023-10-27 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2023.1230760 |
| PMID | 37965367 |
| OpenAlex | W4388191420 |
| Language | EN |
| References cited | 67 |
There is increased risk of psychosis associated with cannabis use disorder and the interaction of THC with dopamine neurotransmission is complex. It is important to investigate the recovery from cannabis-induced psychosis and its effects on the brain's dopamine neurotransmission. This study was to evaluate dopamine receptor D 2 availability in the striatum (caudate/putamen) in recently abstinent cannabis dependent users after recovery from psychosis in comparison with abstinent MDMA "ecstasy" abusers and healthy control participants. Participants were eight abstinent ex cannabis-dependent users who were treated for cannabis-induced psychosis with anti-psychotic medication and psychosocial support for 4 months in an inpatient treatment center for drug users. They were compared with nine abstinent ex MDMA "ecstasy" abusers who received medication and psycho-social treatment for 4 months at the same treatment facility and eight healthy control participants. All participants were scanned with bolus and constant infusion of [ 123 I] Iodobenzamide (IBZM) in Single Photon Computed Tomography (SPECT). Cannabis abstinent users who were treated for cannabis-induced psychotic episodes showed no difference in dopamine D 2 receptor availability in the caudate compared with abstinent MDMA "ecstasy" abusers and healthy control participants. This finding indicates minimal effects of cannabis-induced psychosis on dopamine reward mechanisms. There is evidence for reduced D 2 receptor availability measures in the right putamen (uncorrected) which may indicate a residual effect of anti-psychotic medication
Cannabidiol · Cannabis · Dopamine · Ecstasy · Effects of cannabis · MDMA · Psychiatry · Psychosis · Putamen · Cannabis and Cannabinoid Research · Medicine · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychology · Schizophrenia research and treatment
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Psychometric properties of the Beck Depression Inventory
| Highly cited | No |
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