The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia
Bibliographic Data
| ID | 15527926 |
|---|---|
| Authors | Haiyan Cao (0000-0001-9396-9264, Tianjin Medical University), Yongjie Zhou (0009-0002-9772-949X, Jinzhou Kangning Hospital), Tao Li (0000-0001-7895-4136, Tianjin Medical University), Cong Yao (0000-0001-6564-4796, Tianjin Medical University), Weiliang Yang (Tianjin Anding Hospital), Siying Kong (Tianjin Anding Hospital), Yanyan Wang (0000-0002-6312-206X, Tianjin Medical University), Bao-Ping Yu (Tianjin Medical University), Baoping Yu, Qingyan Jiao (0009-0009-6379-2141, Tianjin Medical University), Yun Sun (0000-0002-9073-8142, Tianjin Medical University), Xiaoju Jia (Tianjin Anding Hospital), Yuting Wang (0000-0002-2272-9404, Tianjin Medical University), Zhonggang Wang (0000-0003-0451-1919), Xiangyang Zhang (0000-0003-3326-382X, Institute of Psychology, Chinese Academy of Sciences, corresponding author), Jie Li (0000-0002-5131-4769, Tianjin Anding Hospital, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 704045-704045 |
| Publication date | 2021-08-16 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.704045 |
| PMID | 34483996 |
| OpenAlex | W3193426432 |
| Language | EN |
| Citations received | 1 |
| References cited | 55 |
Background: The QTc interval may be significantly prolonged in schizophrenia patients taking antipsychotics. Few studies have addressed QTc prolongation (QTP) in Chinese patients. Objectives: This study was designed to evaluate the prevalence of QTP and its clinical correlates in Chinese hospitalized patients with chronic schizophrenia. Methods: A total of 436 inpatients and 291 normal controls matched with age and sex were included. QTc prolongation was defined as 2 standard deviations (SD) above the mean value of normal controls. Positive and Negative Syndrome Scale (PANSS) and its five-factor model were used to evaluate psychopathological symptoms. Results: QTc interval was significantly longer in patients than in normal controls. The prevalence of QTP is 8.26% in Chinese hospitalized patients with chronic schizophrenia. More women than men displayed QTP. Compared with patients without QTP, the patients with QTP had significantly higher concrete/disorganized subscore, lower low density lipoprotein (LDL) and lower total protein (TP). Furthermore, binary logistic regression analysis showed that higher number of hospitalizations, higher concrete/disorganized subscore and lower LDL were risk factors for QTP. Correlation analysis indicated significant association between QTc interval and the following variables: sex, age, duration of illness, the number of hospitalizations, PANSS total score, fasting blood glucose (FPG). Finally, a multiple regression analysis showed that older age, antipsychotic polypharmacy, higher PANSS total score, and lower LDL were risk factors for QTP. Among them, LDL seemed to be a protective factor for QTP. Conclusions: QTc interval was longer in schizophrenia patients than in normal controls. The prevalence of QTP is 8.26% in Chinese hospitalized patients with chronic schizophrenia. Some clinical characteristics were risk factors for QTP. And LDL seemed to be a protective factor for QTP
Antipsychotic · Clozapine · Logistic regression · Polypharmacy · Positive and Negative Syndrome Scale · Psychiatry · Psychosis · QT interval · Risk factor · Schizophrenia (object-oriented programming · Cardiac electrophysiology and arrhythmias · Cardiovascular Function and Risk Factors · Medicine · Schizophrenia research and treatment · Internal Medicine
| Citations per year | 0.33 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |