Decreased Peripheral BDNF Levels and Cognitive Impairment in Late-Life Schizophrenia
Bibliographic Data
| ID | 15528013 |
|---|---|
| Authors | Lijuan Huo (0000-0003-3356-6863, Guangzhou Medical University), Zhiwei Zheng (0000-0002-8205-420X, Institute of Psychology, Chinese Academy of Sciences), Xiaobing Lu (0000-0001-7401-5481, Guangzhou Medical University), Fengchun Wu (0000-0003-2817-2341, Guangzhou Medical University), Yuping Ning (0000-0002-5727-2782, Southern Medical University, corresponding author), Xiangyang Zhang (0000-0003-3326-382X, Guangzhou Medical University, corresponding author), Xiang Yang Zhang (0000-0001-5762-7515) |
| Year | 2021 |
| Volume | 12 |
| Pages | 641278-641278 |
| Publication date | 2021-06-22 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.641278 |
| PMID | 34239458 |
| OpenAlex | W3173936946 |
| Language | EN |
| References cited | 50 |
Objectives: There are relatively few studies on mechanisms of cognitive deficits in late-life schizophrenia (LLS). Brain-derived neurotrophic factor (BDNF), as an important neuroplastic molecule, has been reported to be involved in neurocognitive impairment in schizophrenia. This study aimed to examine whether peripheral BDNF levels were associated with cognitive deficits in LLS, which has not been explored yet. Methods: Forty-eight LLS patients and 45 age-matched elderly controls were recruited. We measured all participants on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition and serum BDNF levels. Psychopathological symptoms in patients were assessed by the Positive and Negative Syndrome Scale (PANSS). Results: The levels of BDNF in LLS patients were significantly lower than those in healthy controls (8.80 ± 2.30 vs. 12.63 ± 5.08 ng/ml, p p ≤ 0.005). BDNF was positively associated with attention in LLS patients ( r = 0.338, p = 0.019). Conclusion: Our findings suggest that older patients with schizophrenia exhibit lower BDNF levels and more cognitive deficits than older controls, supporting the accelerated aging hypothesis of schizophrenia. Moreover, decreased BDNF is related to attention deficits, indicating that BDNF might be a candidate biomarker of cognitive impairments in LLS patients
Biomarker · Brain-derived neurotrophic factor · Cognition · Neurocognitive · Neuropsychology · Neurotrophic factors · Positive and Negative Syndrome Scale · Psychiatry · Psychopathology · Psychosis · Repeatable Battery for the Assessment of Neuropsychological Status · Schizophrenia (object-oriented programming · Clinical Psychology · Medicine · Nerve injury and regeneration · Psychology · Schizophrenia research and treatment · Tryptophan and brain disorders · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |