Body mass index, smoking behavior, and depression mediated the effects of schizophrenia on chronic obstructive pulmonary disease

Trans-ethnic Mendelian-randomization analysis

Bibliographic Data

ID15528128
AuthorsYao Ni (0000-0002-4203-2284, Chengdu Second People's Hospital), Dawei Zhang (0000-0001-8146-0831, Dalian Medical University), Wenlong Tang (0009-0007-5552-4994, Chengdu Second People's Hospital), Liming Xiang (0000-0003-0698-5173, Chengdu Second People's Hospital), Xiaoding Cheng (Chengdu Second People's Hospital), Youqian Zhang (0009-0003-9372-5923, Yangtze University, corresponding author), Yanyan Feng (0009-0003-3222-667X, Chengdu Second People's Hospital, corresponding author)
Year2024
Volume15
Pages1405107-1405107
Publication date2024-05-22
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2024.1405107
PMID38846919
OpenAlexW4398218113
LanguageEN
References cited61

This study confirmed a causal relationship between SCZ and the risk of COPD in EUR ancestry, with BMI, smoking, and MDD serving as key mediators. Future research on a larger scale is necessary to validate the generalizability of these findings across other ancestries

Biology · Body mass index · Confounding · COPD · Disease · Gene · Genetic variants · Genome-wide association study · Genotype · Major depressive disorder · Mediation · Mendelian randomization · Psychiatry · Schizophrenia (object-oriented programming · Single-nucleotide polymorphism · Clinical Psychology · Epigenetics and DNA Methylation · Genetic Associations and Epidemiology · Helicobacter pylori-related gastroenterology studies · Medicine · Genetics · Internal Medicine · Oncology

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