Decreased Response to Positive Facial Affect in a Depressed Cohort in the Dorsal Striatum During a Working Memory Task—A Preliminary fMRI Study
Bibliographic Data
| ID | 15528209 |
|---|---|
| Authors | Peter Goodin (0000-0003-1981-7363, Swinburne University of Technology, corresponding author), Gemma Lamp (0000-0001-7235-0446, La Trobe University), Matthew Hughes (0000-0002-1000-7922, Swinburne University of Technology), Matthew E Hughes, Susan L Rossell (0000-0002-7415-8252, Swinburne University of Technology), Joseph Ciorciari (0000-0002-0751-0631, Swinburne University of Technology) |
| Year | 2019 |
| Volume | 10 |
| Pages | 60-60 |
| Publication date | 2019-03-05 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00060 |
| PMID | 30890968 |
| OpenAlex | W2918973296 |
| Language | EN |
| Citations received | 2 |
| References cited | 92 |
People with depression have shown alterations in processing emotional information and working memory functionality. There is some evidence that emotional content may interact with working memory update processes, however neurological correlates are current unknown. In this preliminary study we utilized a novel version of the emotional variant of the n-back working memory task in fMRI. We examined BOLD response of 14 healthy controls and 13 depressed participants in response to happy, sad, and neutral displays of facial affect. No accuracy or reaction time differences were found between the two groups. The depressed group showed significantly decreased BOLD response to happy faces compared to the control group areas of the dorsal striatum and anterior cingulate. Significant, moderate, positive associations were found between right caudate activation with anxiety score and anterior cingulate activation with depression score in those with depression. Our novel task was able to elicit group level differences in emotional processing during working memory update. These results suggest those with depression fail to differentiate between positive emotional stimuli and stimuli with no emotional content
Affect (linguistics · Audiology · Cognition · Cognitive psychology · Dopamine · Dorsum · Striatum · Task (project management · Ventral striatum · Working memory · Communication · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Psychology · Spatial Neglect and Hemispheric Dysfunction · Transcranial Magnetic Stimulation Studies · Anatomy
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Cognitive and emotional influences in anterior cingulate cortex
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Psychometric properties of the 42-item and 21-item versions of the Depression Anxiety Stress Scales in clinical groups and a community sample.
The earth is round (p < .05)
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2022 - 2022 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |