Sex and Electrode Configuration in Transcranial Electrical Stimulation
Bibliographic Data
| ID | 15528320 |
|---|---|
| Authors | Michael J Russell (0000-0001-9594-022X, corresponding author), Theodore Goodman (Sutter Medical Center), Theodore A Goodman, Joseph M Visse, Lucy Beckett (0000-0002-2418-9843, University of California, Davis), Laurel Beckett, Naomi Saito (0009-0006-7858-9267, University of California, Davis), Bruce G Lyeth (0000-0003-4811-1474, Neurological Surgery), Gregg H Recanzone (0000-0002-9248-6313, University of California, Davis) |
| Year | 2017 |
| Volume | 8 |
| Pages | 147-147 |
| Publication date | 2017-08-14 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2017.00147 |
| PMID | 28855877 |
| OpenAlex | W2740458874 |
| Language | EN |
| References cited | 46 |
Transcranial electrical stimulation (tES) can be an effective non-invasive neuromodulation procedure. Unfortunately, the considerable variation in reported treatment outcomes, both within and between studies, has made the procedure unreliable for many applications. To determine if individual differences in cranium morphology and tissue conductivity can account for some of this variation, the electrical density at two cortical locations (temporal and frontal) directly under scalp electrodes was modeled using a validated MRI modeling procedure in 23 subjects (12 males and 11 females). Three different electrode configurations (non-cephalic, bi-cranial, and ring) commonly used in tES were modeled at three current intensities (0.5, 1.0, and 2.0 mA). The aims were to assess the effects of configuration and current intensity on relative current received at a cortical brain target directly under the stimulating electrode and to characterize individual variation. The different electrode configurations resulted in up to a ninefold difference in mean current densities delivered to the brains. The ring configuration delivered the least current and the non-cephalic the most. Female subjects showed much less current to the brain than male subjects. Individual differences in the current received and differences in electrode configurations may account for significant variability in current delivered and, thus, potentially a significant portion of reported variation in clinical outcomes at two commonly targeted regions of the brain
Electrode · Physical medicine and rehabilitation · Physics · Stimulation · Transcranial Direct Current Stimulation · Medicine · Muscle activation and electromyography studies · Neuroscience · Psychology · Transcranial Magnetic Stimulation Studies · Vestibular and auditory disorders
| Citation velocity | historical |
|---|---|
| Highly cited | No |