Deficits during Voluntary Selection in Adult Patients with ADHD

New Insights from Single-Trial Coupling of Simultaneous EEG/fMRI

Bibliographic Data

ID15528454
AuthorsSusanne Karch (0000-0002-1542-1110, Ludwig-Maximilians-Universität München), Julia Madeleine Voelker (Ludwig-Maximilians-Universität München), Tobias Thalmeier (Ludwig-Maximilians-Universität München), Matthias Ertl (0000-0002-6823-1935, Universität Hamburg), Gregor Leicht (0000-0002-5104-9336, University Medical Center Hamburg-Eppendorf), Oliver Pogarell (0000-0001-6455-4190, Ludwig-Maximilians-Universität München), Christoph Mulert (0000-0001-8214-5868, Universität Hamburg, corresponding author)
Year2014
Volume5
Pages41-41
Publication date2014-04-22
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2014.00041
PMID24795657
PMCIDPMC4001047
OpenAlexW2046976052
LanguageEN
Citations received1
References cited67

Deficits in executive functions, including voluntary decisions are among the core symptoms of attention deficit/hyperactivity disorder (ADHD) patients. In order to clarify the spatiotemporal characteristics of these deficits, a simultaneous EEG/functional MRI (fMRI) study was performed. Single-trial coupling was used to integrate temporal EEG information in the fMRI analyses and to correlate the trial by trial variation in the different event-related potential amplitudes with fMRI BOLD responses. The results demonstrated that during voluntary selection early electrophysiological responses (N2) were associated with responses in similar brain regions in healthy participants as well as in ADHD patients, e.g., in the medial-frontal cortex and the inferior parietal gyrus. However, ADHD patients presented significantly reduced N2-related BOLD responses compared to healthy controls especially in frontal areas. These results support the hypothesis that in ADHD patients executive deficits are accompanied by early dysfunctions, especially in frontal brain areas

Audiology · Brain activity and meditation · EEG-fMRI · Electroencephalography · Functional magnetic resonance imaging · Superior frontal gyrus · Attention Deficit Hyperactivity Disorder · Functional Brain Connectivity Studies · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Psychology

Tools

Open DOISci-HubOpen Access