Prediction of Clinical Outcomes With EEG Microstate in Patients With Major Depressive Disorder
Bibliographic Data
| ID | 15528483 |
|---|---|
| Authors | Danfeng Yan (0000-0002-1439-2274, Second Xiangya Hospital of Central South University), Jin Liu (0000-0001-5816-2422, Central South University), Mei Liao (0000-0001-9906-3199, Central South University), Bangshan Liu (0000-0002-9355-2183, Second Xiangya Hospital of Central South University), Shibin Wu (0000-0003-3352-2270, First People's Hospital of Nanning), Xueqin Li (0000-0002-1501-4371, Hunan Institute of Mental Health), Haolun Li (0000-0003-3829-2849, Central South University), Wenwen Ou (Second Xiangya Hospital of Central South University), Li Zhang (0000-0002-4441-5131, Second Xiangya Hospital of Central South University), Zexuan Li (0009-0004-7067-6572, Central South University), Yan Zhang (0000-0001-8460-2671, Central South University), Lingjiang Li (0000-0002-8775-7852, Hunan Institute of Mental Health, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 695272-695272 |
| Publication date | 2021-08-16 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.695272 |
| PMID | 34483990 |
| OpenAlex | W3196113124 |
| Language | EN |
| Citations received | 1 |
| References cited | 30 |
Background: The difficulty in timely evaluating patient response to antidepressants has brought great challenge to the treatment of major depressive disorder (MDD). Some studies found that the electroencephalogram (EEG) microstates might be a reliable marker to evaluate patient response to treatment. The present study aims to evaluate the relationship between EEG microstate parameters and MDD symptoms before and after treatment to identify predictive biological markers for patient response. Methods: Thirty drug-naïve MDD patients (20 females and 10 males) were enrolled in this study. All the patients received effective dosages of selective serotonin reuptake inhibitors, and EEG recordings were collected at baseline and 2 weeks of treatment. Brain activities during the eyes-closed state were recorded using 64-channel electroencephalography, and the patients' microstates were clustered into four maps according to their topography (labeled A, B, C, and D). The differences of EEG microstates before and after treatment were compared using paired t -test. Spearman correlation coefficients were calculated to identify the relationships between the improvement of depression and anxiety symptoms and microstate parameters. Results: The mean duration (69.67 ± 10.33 vs. 64.00 ± 7.70, p p = 0.002) of microstate B decreased significantly after treatment. The proportion of microstate B also decreased (27.53 ± 5.81, vs. 23.23 ± 4.61, p r = -0.431, p Conclusion: This study explored the relationship between changes of EEG microstates and patient response to antidepressants. Depression symptoms might be associated with the duration of microstate B and anxiety symptoms related to the occurrence of microstate A. Therefore, the duration of microstate B and the occurrence of microstate A are potential biological markers for MDD patients' early response and further clinical outcomes
Anxiety · Audiology · Cognition · Correlation · Depression (economics · Electroencephalography · Major depressive disorder · Ministate · Psychiatry · EEG and Brain-Computer Interfaces · Functional Brain Connectivity Studies · Medicine · Neural and Behavioral Psychology Studies · Psychology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,2 |
| Citation span | 2021 - 2021 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |