Alterations in rat prefrontal cortex kynurenic acid levels are involved in the enduring cognitive dysfunctions induced by tetrahydrocannabinol exposure during the adolescence
Bibliographic Data
| ID | 15528504 |
|---|---|
| Authors | Sarah Beggiato (0000-0002-8826-7556, University of Chieti-Pescara, corresponding author), Alessandro Ieraci (0000-0001-6737-7695, University of Milan), Mariachiara Zuccarini (0000-0001-8485-9012, University of Chieti-Pescara), Patrizia Di Iorio (0000-0002-0804-7925, University of Chieti-Pescara), Robert Schwarcz (0000-0003-0486-129X, University of Maryland, Baltimore), Luca Ferraro (0000-0003-2390-6414, University of Ferrara) |
| Year | 2022 |
| Volume | 13 |
| Pages | 996406-996406 |
| Publication date | 2022-11-22 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.996406 |
| PMID | 36483135 |
| OpenAlex | W4309735499 |
| Language | EN |
| References cited | 5 |
We propose that the observed alterations in PFC KYNA signaling might be involved in the cognitive dysfunction induced by the exposure to THC during the adolescence. In the translational realm, these experiments raise the prospect of prevention of KYNA neosynthesis as a possible novel approach to counteract some of the detrimental long-term effects of adolescence cannabis use
Cognition · Dopamine · Glutamate receptor · Kynurenic acid · Kynurenine · Microdialysis · Prefrontal cortex · Radial arm maze · Tryptophan · Working memory · Bipolar Disorder and Treatment · Cannabis and Cannabinoid Research · Chemistry · Medicine · Neuroscience · Psychology · Tryptophan and brain disorders · Biochemistry · Endocrinology · Internal Medicine · Pharmacology
| Highly cited | No |
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