Oxytocin-Induced Changes in Intrinsic Network Connectivity in Cocaine Use Disorder
Modulation by Gender, Childhood Trauma, and Years of Use
Bibliographic Data
| ID | 15528573 |
|---|---|
| Authors | Jane E Joseph (0000-0002-8180-7206, Medical University of South Carolina, corresponding author), Brandon Vaughan (Medical University of South Carolina), Chris Camp (0000-0003-2960-8872, Medical University of South Carolina), Nathaniel L Baker (0000-0003-3313-1579, Medical University of South Carolina), Brian J Sherman (0000-0001-8097-3061, Medical University of South Carolina), Megan M Moran‐Santa Maria (Medical University of South Carolina), Aimee L McRae‐Clark (0000-0002-9774-318X, Ralph H. Johnson VA Medical Center), Kathleen T Brady (0000-0002-3944-8051, Ralph H. Johnson VA Medical Center) |
| Year | 2019 |
| Volume | 10 |
| Pages | 502-502 |
| Publication date | 2019-07-19 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00502 |
| PMID | 31379621 |
| OpenAlex | W2960208233 |
| Language | EN |
| Citations received | 1 |
| References cited | 17 |
Cocaine use disorder (CUD) is a major public health concern with devastating social, economic, and mental health implications. A better understanding of the underlying neurobiology and phenotypic variations in individuals with CUD is necessary for the development of effective and targeted treatments. In this study, 39 women and 54 men with CUD completed a 6-min resting-state functional magnetic resonance imaging scan after intranasal oxytocin (OXY) or placebo administration. Graph-theory network analysis was used to quantify functional connectivity changes caused by OXY in striatum, anterior cingulate cortex (ACC), insula, and amygdala nodes of interest. OXY increased connectivity in the right ACC and left amygdala in males, whereas OXY increased connectivity in the right ACC and right accumbens in females. Machine learning was then used to associate treatment response (placebo minus OXY) in nodes of interest with years of cocaine use and severity of childhood trauma separately for males and females. Childhood trauma and years of cocaine use were associated with OXY-induced changes in ACC connectivity for both men and women, but connectivity changes in the amygdala were associated with years of cocaine use in men and connectivity changes in the right insula were associated with years of cocaine use in women. These findings suggest that salience network nodes (ACC and insula) are potential OXY treatment targets in CUD, with the amygdala as a treatment target for men and the accumbens as a treatment target for women
Developmental psychology · Oxytocin · Psychiatry · Attachment and Relationship Dynamics · Clinical Psychology · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Neuroendocrine regulation and behavior · Neuroscience · Psychology
Saliency, switching, attention and control
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Complex network measures of brain connectivity
Timeline Follow-Back
Stress signalling pathways that impair prefrontal cortex structure and function
Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion
Controlling the False Discovery Rate
Collective dynamics of ‘small-world’ networks
Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence
Cortico-Amygdala Coupling as a Marker of Early Relapse Risk in Cocaine-Addicted Individuals
Protocol for an experimental investigation of the roles of oxytocin and social support in neuroendocrine, cardiovascular, and subjective responses to stress across age and gender
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,13 |
| Citation span | 2018 - 2018 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |