Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder

Bibliographic Data

ID15528632
AuthorsHuibin Jia (0000-0002-5809-2572, Henan University, corresponding author), Fei Gao (0000-0001-9964-2457, Peking University People's Hospital), Dongchuan Yu (0000-0001-5576-441X, Southeast University, corresponding author)
Year2021
Volume12
Pages618573-618573
Publication date2021-11-10
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.618573
PMID34899403
OpenAlexW3211774996
LanguageEN
References cited42

Functional connectivity, quantified by phase synchrony, between brain regions is known to be aberrant in patients with autism spectrum disorder (ASD). Here, we evaluated the long-range temporal correlations of time-varying phase synchrony (TV-PS) of electrocortical oscillations in patients with ASD as well as typically developing people using detrended fluctuation analysis (DFA) after validating the scale-invariance of the TV-PS time series. By comparing the DFA exponents between the two groups, we found that those of the TV-PS time series of high-gamma oscillations were significantly attenuated in patients with ASD. Furthermore, the regions involved in aberrant TV-PS time series were mainly within the social ability and cognition-related cortical networks. These results support the notion that abnormal social functions observed in patients with ASD may be caused by the highly volatile phase synchrony states of electrocortical oscillations

Audiology · Autism · Autism spectrum disorder · Biology · Cognition · Detrended fluctuation analysis · Developmental psychology · Series (stratigraphy · Typically developing · EEG and Brain-Computer Interfaces · Functional Brain Connectivity Studies · Mathematics · Medicine · Neural dynamics and brain function · Neuroscience · Psychology

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