A Preliminary Study of White Matter in Adolescent Depression

Relationships with Illness Severity, Anhedonia, and Irritability

Datos Bibliográficos

ID15528645
AutoresSarah Henderson (0000-0002-4660-2758, Icahn School of Medicine at Mount Sinai), Sarah E Henderson, Amy R Johnson (0000-0001-9534-9093, Icahn School of Medicine at Mount Sinai), Ana I Vallejo (Icahn School of Medicine at Mount Sinai), Lev Katz (Icahn School of Medicine at Mount Sinai), Edmund Wong (Icahn School of Medicine at Mount Sinai), Vilma Gabbay (0000-0001-8819-5137, Icahn School of Medicine at Mount Sinai, autor de correspondencia)
Año2013
Volumen4
Páginas152-152
Fecha de publicación2013-01-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaFrontiers in Psychiatry (JOURNAL)
Identificadores de la revistaISSN: 1664-0640 • E-ISSN: 1664-0640
EditorialFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2013.00152
PMID24324445
PMCIDPMC3839092
OpenAlexW2043319706
IdiomaEN
Citas recibidas2
Referencias citadas10

Major depressive disorder (MDD) during adolescence is a common and disabling psychiatric condition; yet, little is known about its neurobiological underpinning. Evidence indicates that MDD in adults involves alterations in white and gray matter; however, sparse research has focused on adolescent MDD. Similarly, little research has accounted for the wide variability of symptom severity among depressed teens. Here, we aimed to investigate white matter (WM) microstructure between 17 adolescents with MDD and 16 matched healthy controls (HC) using diffusion tensor imaging. We further assessed within the MDD group relationships between WM integrity and depression severity, as well as anhedonia and irritability - two core symptoms of adolescent MDD. As expected, adolescents with MDD manifested decreased WM integrity compared to HC in the anterior cingulum and anterior corona radiata. Within the MDD group, greater depression severity was correlated with reduced WM integrity in the genu of corpus callosum, anterior thalamic radiation, anterior cingulum, and sagittal stratum. However, anhedonia and irritability were associated with alterations in distinct WM tracts. Specifically, anhedonia was associated with disturbances in tracts related to reward processing, including the anterior limb of the internal capsule and projection fibers to the orbitofrontal cortex. Irritability was associated with decreased integrity in the sagittal stratum, anterior corona radiata, and tracts leading to prefrontal and temporal cortices. Overall, these preliminary findings provide further support for the hypotheses that there is a disconnect between prefrontal and limbic emotional regions in depression, and that specific clinical symptoms involve distinct alterations in WM tracts

Amygdala · Anhedonia · Anterior cingulate cortex · Anxiety · Cingulum (brain · Corona radiata (embryology) · Corpus callosum · Depression (economics · Fractional anisotropy · Irritability · Magnetic resonance imaging · Major depressive disorder · Psychiatry · Schizophrenia (object-oriented programming · Uncinate fasciculus · White matter · Advanced MRI Techniques and Applications · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Internal Medicine