Distinguishing Between Treatment-Resistant and Non-Treatment-Resistant Schizophrenia Using Regional Homogeneity
Bibliographic Data
| ID | 15529040 |
|---|---|
| Authors | Shuzhan Gao (0009-0000-4051-1276, Nanjing University), Shuiping Lu (Nanjing Brain Hospital), Xiaomeng Shi (0009-0007-7072-5110, Nanjing Medical University), Yidan Ming (Nanjing University), Chaoyong Xiao (Nanjing Brain Hospital), Jing Sun (0000-0003-0850-322X, Nanjing Brain Hospital), Hui Yao (0000-0003-1343-8338, Nanjing Medical University), Xijia Xu (0000-0002-0598-7188, Nanjing Brain Hospital, corresponding author) |
| Year | 2018 |
| Volume | 9 |
| Pages | 282-282 |
| Publication date | 2018-08-06 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00282 |
| PMID | 30127752 |
| OpenAlex | W2807880583 |
| Language | EN |
| Citations received | 2 |
| References cited | 44 |
Background: Patients with treatment-resistant schizophrenia (TRS) and non-treatment-resistant schizophrenia (NTRS) respond to antipsychotic drugs differently. Previous studies demonstrated that patients with TRS or NTRS exhibited abnormal neural activity in different brain regions. Accordingly, in the present study, we tested the hypothesis that a regional homogeneity (ReHo) approach could be used to distinguish between patients with TRS and NTRS. Methods: A total of 17 patients with TRS, 17 patients with NTRS, and 29 healthy controls (HCs) matched in sex, age, and education levels were recruited to undergo resting-state functional magnetic resonance imaging (RS-fMRI). ReHo was used to process the data. ANCOVA followed by post-hoc t -tests, receiver operating characteristic curves (ROC), and correlation analyses were applied for the data analysis. Results: ANCOVA analysis revealed widespread differences in ReHo among the three groups in the occipital, frontal, temporal, and parietal lobes. ROC results indicated that the optimal sensitivity and specificity of the ReHo values in the left postcentral gyrus, left inferior frontal gyrus/triangular part, and right fusiform could differentiate TRS from NTRS, TRS from HCs, and NTRS from HCs were 94.12 and 82.35%, 100 and 86.21%, and 82.35 and 93.10%, respectively. No correlation was found between abnormal ReHo and clinical symptoms in patients with TRS or NTRS. Conclusions: TRS and NTRS shared most brain regions with abnormal neural activity. Abnormal ReHo values in certain brain regions might be applied to differentiate TRS from NTRS, TRS from HC, and NTRS from HC with high sensitivity and specificity
Correlation · Functional magnetic resonance imaging · Magnetic resonance imaging · Radiology · Receiver operating characteristic · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Schizophrenia research and treatment · Internal Medicine
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,33 |
| Citation span | 2020 - 2024 (5) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 2 |