Altered Gray Matter Volume and Resting-State Connectivity in Individuals With Internet Gaming Disorder

A Voxel-Based Morphometry and Resting-State Functional Magnetic Resonance Imaging Study

Dados Bibliográficos

ID15529152
AutoresJi-Woo Seok, Ji‐Woo Seok (0000-0001-5690-2802, Honam University), Jin-Hun Sohn, Jin‐Hun Sohn (0000-0002-1062-3282, Chungnam National University, autor correspondente)
Ano2018
Volume9
Páginas77-77
Data de publicação2018-03-27
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoFrontiers in Psychiatry (JOURNAL)
Identificadores do periódicoISSN: 1664-0640 • E-ISSN: 1664-0640
EditoraFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2018.00077
PMID29636704
OpenAlexW2795193680
IdiomaEN
Citações recebidas8
Referências citadas49

Neuroimaging studies on the characteristics of individuals with Internet gaming disorder (IGD) have been accumulating due to growing concerns regarding the psychological and social problems associated with Internet use. However, relatively little is known about the brain characteristics underlying IGD, such as the associated functional connectivity and structure. The aim of this study was to investigate alterations in gray matter (GM) volume and functional connectivity during resting state in individuals with IGD using voxel-based morphometry and a resting-state connectivity analysis. The participants included 20 individuals with IGD and 20 age- and sex-matched healthy controls. Resting-state functional and structural images were acquired for all participants using 3 T magnetic resonance imaging. We also measured the severity of IGD and impulsivity using psychological scales. The results show that IGD severity was positively correlated with GM volume in the left caudate ( p p < 0.05, corrected for multiple comparisons). This study demonstrates that IGD is associated with neuroanatomical changes in the right middle frontal cortex and the left caudate. These are important brain regions for reward and cognitive control processes, and structural and functional abnormalities in these regions have been reported for other addictions, such as substance abuse and pathological gambling. The findings suggest that structural deficits and resting-state functional impairments in the frontostriatal network may be associated with IGD and provide new insights into the underlying neural mechanisms of IGD

Cognition · Functional connectivity · Functional magnetic resonance imaging · Immunoglobulin D · Impulsivity · Magnetic resonance imaging · Middle frontal gyrus · Neural correlates of consciousness · Neuroimaging · Psychiatry · Resting state fMRI · Superior frontal gyrus · Voxel · Voxel-based morphometry · White matter · Eating Disorders and Behaviors · Impact of Technology on Adolescents · Medicine · Neuroscience · Psychology