Immediate Effects of tDCS on the μ-Opioid System of a Chronic Pain Patient
Bibliographic Data
| ID | 15529181 |
|---|---|
| Authors | Marcos Fabio Dos Santos (University of Michigan, corresponding author), Tiffany Love (0000-0001-9299-3190, University of Michigan), Tiffany M Love, Ilkka K Martikainen (0000-0002-6025-6994, Michigan United), Thiago D Nascimento (0000-0003-0910-9005, Michigan United), Felipe Fregni (0000-0001-9359-8643, Harvard University), Chelsea M Cummiford (University of Michigan), Chelsea Cummiford, Misty DeBoer (Michigan United), Misty Dawn Deboer, Jon‐Kar Zubieta (University of Michigan), Jon-Kar Zubieta, Alexandre F DaSilva (0000-0003-3138-7781, University of Michigan), Alexandre F M DaSilva |
| Year | 2012 |
| Volume | 3 |
| Pages | 93-93 |
| Publication date | 2012-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2012.00093 |
| PMID | 23130002 |
| PMCID | PMC3486958 |
| OpenAlex | W2012444063 |
| Language | EN |
| Citations received | 3 |
| References cited | 1 |
We developed a unique protocol where transcranial direct current stimulation (tDCS) of the motor cortex is performed during positron emission tomography (PET) scan using a μ-opioid receptor (μOR) selective radiotracer, [(11)C]carfentanil. This is one of the most important central neuromechanisms associated with pain perception and regulation. We measured μOR non-displaceable binding potential (μOR BP(ND)) in a trigeminal neuropathic pain patient (TNP) without creating artifacts, or posing risks to the patient (e.g., monitoring of resistance). The active session directly improved in 36.2% the threshold for experimental cold pain in the trigeminal allodynic area, mandibular branch, but not the TNP patient's clinical pain. Interestingly, the single active tDCS application considerably decreased μORBP(ND) levels in (sub)cortical pain-matrix structures compared to sham tDCS, especially in the posterior thalamus. Suggesting that the μ-opioidergic effects of a single tDCS session are subclinical at immediate level, and repetitive sessions are necessary to revert ingrained neuroplastic changes related to the chronic pain. To our knowledge, we provide data for the first time in vivo that there is possibly an instant increase of endogenous μ-opioid release during acute motor cortex neuromodulation with tDCS
Anesthesia · Chronic pain · Endogenous opioid · Neuromodulation · Neuropathic pain · Neuroplasticity · Opioid · Opioidergic · Physical therapy · Receptor · Stimulation · Transcranial Direct Current Stimulation · Trigeminal neuralgia · Medicine · Neuroscience · Pain Management and Treatment · Pain Mechanisms and Treatments · Psychology · Transcranial Magnetic Stimulation Studies · Internal Medicine
| Citations per year | 0.23 |
|---|---|
| Citation span | 2013 - 2017 (5) |
| Highly cited | No |