Sex-Dependent Alterations of Regional Homogeneity in Cigarette Smokers
Bibliographic Data
| ID | 15529261 |
|---|---|
| Authors | Zhi Wen (0000-0002-8756-7645, Wuhan University), Xu Han (0000-0003-4414-8341, Shanghai Jiao Tong University), Yao Wang (0000-0002-7024-4233, Shanghai Jiao Tong University), Weina Ding (Shanghai Jiao Tong University), Yawen Sun (0000-0001-6529-8598, Shanghai Jiao Tong University), Yan Kang (0000-0001-6233-0652, Wuhan Institute of Physics and Mathematics), Yan Zhou (0000-0002-3659-5881, Shanghai Jiao Tong University), Hao Lei (0000-0003-3412-1241, University of Chinese Academy of Sciences), Fuchun Lin (0000-0002-2282-6474, Chinese Academy of Sciences, corresponding author) |
| Year | 2022 |
| Volume | 13 |
| Pages | 874893-874893 |
| Publication date | 2022-04-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.874893 |
| PMID | 35546937 |
| OpenAlex | W4224861771 |
| Language | EN |
| References cited | 7 |
Biological sex may play a large role in cigarette use and cessation outcomes and neuroimaging studies have demonstrated that cigarette smoking is associated with sex-related differences in brain structure and function. However, less is known about sex-specific alterations in spontaneous brain activity in cigarette smokers. In this study, we investigated the sex-related effects of cigarette smoking on local spontaneous brain activity using regional homogeneity (ReHo) based on resting-state fMRI. Fifty-six smokers (24 females) and sixty-three (25 females) healthy non-smoking controls were recruited. Whole-brain voxelwise 2-way analysis of covariance of ReHo was performed to detect brain regions with sex-dependent alterations on the spontaneous brain activity. Compared to non-smokers, smokers exhibited significant ReHo differences in several brain regions, including the right medial orbitofrontal cortex extended to the ventral striatum/amygdala/parahippocampus, left precuneus, and bilateral cerebellum crus. Smoking and sex interaction analysis revealed that male smokers showed significantly lower ReHo in the right ventral striatum, left cerebellum crus1, and left fusiform gyrus compared to male non-smokers, whereas there are no significant differences between female smokers and non-smokers. Furthermore, the ReHo within the left cerebellum crus1 was negatively correlated with craving scores in male smokers but not in female smokers. Such sex-dependent differences in spontaneous brain activity lays a foundation for further understanding the neural pathophysiology of sex-specific effects of nicotine addiction and promoting more effective health management of quitting smoking
Addiction · Amygdala · Brain activity and meditation · Cognition · Electroencephalography · Functional magnetic resonance imaging · Neuroimaging · Nicotine · Orbitofrontal cortex · Precuneus · Prefrontal cortex · Psychiatry · Resting state fMRI · Striatum · Ventral striatum · Functional Brain Connectivity Studies · Medicine · Neural dynamics and brain function · Neuroscience · Nicotinic Acetylcholine Receptors Study · Psychology · Internal Medicine · Physiology
Searching for a baseline
Regional homogeneity approach to fMRI data analysis
Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings
The Fagerström Test for Nicotine Dependence
Interaction Between Smoking and Internet Gaming Disorder on Spontaneous Brain Activity
| Citation velocity | historical |
|---|---|
| Highly cited | No |