Aberrant dynamic minimal spanning tree parameters within default mode network in patients with autism spectrum disorder
Bibliographic Data
| ID | 15529296 |
|---|---|
| Authors | Huibin Jia (0000-0002-5809-2572, Henan University), Xiangci Wu (Henan University), Zhiyu Wu (Cixian People's Hospital), Enguo Wang (0000-0002-6213-1810, Henan University, corresponding author) |
| Year | 2022 |
| Volume | 13 |
| Pages | 860348-860348 |
| Publication date | 2022-09-15 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.860348 |
| PMID | 36186871 |
| OpenAlex | W4295942458 |
| Language | EN |
| References cited | 41 |
The altered functional connectivity (FC) level and its temporal characteristics within certain cortical networks, such as the default mode network (DMN), could provide a possible explanatory framework for Autism spectrum disorder (ASD). In the current study, we hypothesized that the topographical organization along with its temporal dynamics of the autistic brain measured by temporal mean and variance of complex network measures, respectively, were significantly altered, which may further explain the autistic symptom severity in patients with ASD. To validate these hypotheses, the precise FCs between DMN regions at each time point were calculated using the resting-state functional magnetic resonance imaging (fMRI) datasets from the Autism Brain Imaging Data Exchange (ABIDE) project. Then, the minimal spanning tree (MST) technique was applied to construct a time-varying complex network of DMN. By analyzing the temporal mean and variance of MST parameters and their relationship with autistic symptom severity, we found that in persons with ASD, the information exchange efficiencies between cortical regions within DMN were significantly lower and more volatile compared with those in typical developing participants. Moreover, these alterations within DMN were closely associated with the autistic symptom severity of the ASD group
Audiology · Autism · Autism spectrum disorder · Default mode network · Developmental psychology · Dynamic functional connectivity · Functional magnetic resonance imaging · Neurodevelopmental disorder · Resting state fMRI · Advanced MRI Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neural dynamics and brain function · Neuroscience · Psychology
Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014
A fast diffeomorphic image registration algorithm
Statistical parametric maps in functional imaging
Dparsf
Complex network measures of brain connectivity
Dpabi
Unified segmentation
The control of the false discovery rate in multiple testing under dependency
Movement‐Related effects in fMRI time‐series
Functional-Anatomic Fractionation of the Brain's Default Network
| Citation velocity | historical |
|---|---|
| Highly cited | No |