Cerebellar Structural Abnormalities Associated With Cognitive Function in Patients With First-Episode Psychosis
Bibliographic Data
| ID | 15529314 |
|---|---|
| Authors | Taekwan Kim (0000-0002-1901-8636, Seoul National University), Kwang-Hyuk Lee (Seoul National University), Hyerim Oh (Seoul National University), Tae Young Lee (0000-0002-0238-8147, Seoul National University Hospital), Kang Ik K Cho (0000-0001-7135-3848, Seoul National University), Junhee Lee (0000-0003-4327-1911, Seoul National University), Jun Soo Kwon (0000-0002-1060-1462, Seoul National University, corresponding author) |
| Year | 2018 |
| Volume | 9 |
| Pages | 286-286 |
| Publication date | 2018-07-03 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00286 |
| PMID | 30018573 |
| OpenAlex | W2811430334 |
| Language | EN |
| References cited | 73 |
Introduction: The fundamental role of the cerebellum in higher cognitive processing has recently been highlighted. However, inconsistent findings exist in schizophrenia with respect to the exact nature of cerebellar structural abnormalities and their associations with cognitive and clinical features. Materials and Methods: We undertook a detailed investigation of cerebellar lobular volumes in 40 patients with first-episode psychosis (FEP) and 40 healthy controls (HCs) using the spatially unbiased atlas template of the cerebellum (SUIT). We examined the functional significance of cerebellar structural abnormalities in relation to cognitive and clinical outcomes in patients. Results: We found that left cerebellar lobules VI and X volumes were lower in FEP patients, compared to HCs. Smaller left lobules VI and X volumes were associated with fewer number of categories completed on the Wisconsin Card Sorting Test (WCST) in patients. In addition, smaller left lobule X volume was related to performance delay on the Trail Making Test (TMT) Part B in patients. Conclusion: Our results demonstrate that cerebellar structural abnormalities are present at the early stage of schizophrenia. We suggest functional associations of cerebellar structural changes with non-verbal executive dysfunctions in FEP
Cognition · Psychiatry · Psychosis · Clinical Psychology · Epilepsy research and treatment · Medicine · Neuroscience · Psychology · Psychosomatic Disorders and Their Treatments · Schizophrenia research and treatment
The Global Assessment Scale
A fast diffeomorphic image registration algorithm
Trail Making Test A and B
The Stroop Color and Word Test
Whole Brain Segmentation
Neurocognitive Deficits and Functional Outcome in Schizophrenia
Unified segmentation
Voxel-Based Morphometry—The Methods
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
| Highly cited | No |
|---|