Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia
Bibliographic Data
| ID | 15529336 |
|---|---|
| Authors | Alkomiet Hasan (0000-0002-2662-9742, Ludwig-Maximilians-Universität München, corresponding author), Theresa Bergener (University of Göttingen), Michael A Nitsche (0000-0002-2207-5965, University of Göttingen), Wolfgang Strube (0000-0003-2380-7651, Ludwig-Maximilians-Universität München), Tilmann Bunse (Ludwig-Maximilians-Universität München), Peter Falkai (0000-0003-2873-8667, Ludwig-Maximilians-Universität München), Thomas Wobrock (0000-0002-2835-851X, Klinikum Darmstadt) |
| Year | 2013 |
| Volume | 4 |
| Pages | 121-121 |
| Publication date | 2013-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2013.00121 |
| PMID | 24109457 |
| PMCID | PMC3790105 |
| OpenAlex | W2163072720 |
| Language | EN |
| References cited | 7 |
Transcranial direct current stimulation (tDCS) is a non-invasive stimulation technique that can be applied to modulate cortical activity through induction of cortical plasticity. Since various neuropsychiatric disorders are characterized by fluctuations in cortical activity levels (e.g., schizophrenia), tDCS is increasingly investigated as a treatment tool. Several studies have shown that the induction of cortical plasticity following classical, unilateral tDCS is reduced or impaired in the stimulated and non-stimulated primary motor cortices (M1) of patients with schizophrenia. Moreover, an alternative, bilateral tDCS setup has recently been shown to modulate cortical plasticity in both hemispheres in healthy subjects, highlighting another potential treatment approach. Here we present the first study comparing the efficacy of unilateral tDCS (cathode left M1, anode right supraorbital) with simultaneous bilateral tDCS (cathode left M1, anode right M1) in patients with schizophrenia. tDCS-induced cortical plasticity was monitored by investigating motor-evoked potentials induced by single-pulse transcranial magnetic stimulation applied to both hemispheres. Healthy subjects showed a reduction of left M1 excitability following unilateral tDCS on the stimulated left hemisphere and an increase in right M1 excitability following bilateral tDCS. In schizophrenia, no plasticity was induced following both stimulation paradigms. The pattern of these results indicates a complex interplay between plasticity and connectivity that is impaired in patients with schizophrenia. Further studies are needed to clarify the biological underpinnings and clinical impact of these findings
Brain stimulation · Motor cortex · Neuroplasticity · Primary motor cortex · Psychiatry · Schizophrenia (object-oriented programming · Stimulation · Transcranial Direct Current Stimulation · Transcranial magnetic stimulation · Medicine · Motor Control and Adaptation · Neural and Behavioral Psychology Studies · Neuroscience · Psychology · Transcranial Magnetic Stimulation Studies
The Global Assessment Scale
Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
The assessment and analysis of handedness
A Randomized Double-Blind Sham-Controlled Study of Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression
| Highly cited | No |
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