The role of brain creatine in behavioral health conditions

Bibliographic Data

ID15529688
AuthorsEllie Seunga Han (Huntsman (United States), corresponding author), James R Yancey (0000-0002-8912-8929, Huntsman (United States)), Deborah Yurgelun‐Todd (0000-0002-7242-4190, Huntsman (United States)), Deborah A Yurgelun-Todd, Douglas G Kondo (0000-0003-2066-777X, Huntsman (United States)), Danielle Boxer (0000-0001-7000-745X, Huntsman (United States)), Danielle J Boxer, Perry F Renshaw (0000-0002-8888-4503, Huntsman (United States))
Year2025
Volume16
Pages1667639-1667639
Publication date2025-11-07
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2025.1667639
PMID41280460
OpenAlexW4415982993
LanguageEN
References cited97

Creatine, as a naturally occurring organic compound, has gained attention for its potential role in psychiatric health. The creatine kinase-phosphocreatine energy buffer system plays a crucial role in maintaining energy supply in the brain. Brain bioenergetic deficits, particularly those related to mitochondrial dysfunction, plays a critical role in the pathophysiology of psychiatric illnesses. A growing body of literature has focused on the potential therapeutic role of creatine supplementation in psychiatric illnesses. This review summarizes findings from preclinical, epidemiological, clinical and neuroimaging studies to examine creatine's role as both a biomarker and therapeutic agent in psychiatric disorders, including Major Depressive Disorder, Anxiety Disorders, Posttraumatic Stress Disorder, and Substance Use Disorder

Anxiety · Biomarker · Creatine · Depression (economics · Major depressive disorder · Neuroimaging · Pathophysiology · Coffee research and impacts · Genetics and Physical Performance · Muscle metabolism and nutrition

Tools

Open DOIOpen Access