Metabolomics Analysis of the Prefrontal Cortex in a Rat Chronic Unpredictable Mild Stress Model of Depression

Bibliographic Data

ID15529754
AuthorsLihua Duan (0000-0002-1631-4675, Central South University), Rong Fan (0000-0002-3388-0847, Xiangya Hospital Central South University), Teng Li (0000-0002-3724-5349, Xiangya Hospital Central South University), Zhaoyu Yang (0000-0002-9106-0724, Xiangya Hospital Central South University), En Hu (0000-0002-1000-7260, Central South University), Zhe Yu (0000-0002-6908-6135, Central South University), Jing Tian (0000-0001-7746-7782, Xiangya Hospital Central South University), Weikang Luo (0000-0002-1354-634X, Xiangya Hospital Central South University), Chunhu Zhang (0000-0001-8829-3319, Central South University, corresponding author)
Year2022
Volume13
Pages815211-815211
Publication date2022-03-15
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2022.815211
PMID35370823
OpenAlexW4220908644
LanguageEN
Citations received1
References cited64

Five potential biomarkers were identified in the PFC and metabolite-protein interactions associated with metabolic pathophysiological processes were explored using the CUMS model. The results of this study will assist physicians and scientists in discovering potential diagnostic markers and novel therapeutic targets for depression

Bioinformatics · Biology · Chronic stress · Cognition · Depression (economics · Metabolomics · Prefrontal cortex · Psychiatry · Clinical Psychology · Medicine · Neuroscience · Psychology · Stress Responses and Cortisol · Treatment of Major Depression · Tryptophan and brain disorders · Internal Medicine

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