Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder
Bibliographic Data
| ID | 15529974 |
|---|---|
| Authors | Ji-Woo Suk (University of Nebraska Medical Center), Soonjo Hwang (0000-0001-5117-2468, University of Nebraska Medical Center), Chaejoon Cheong (0000-0002-8218-2965, Korea Basic Science Institute, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 742228-742228 |
| Publication date | 2021-10-20 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.742228 |
| PMID | 34744834 |
| OpenAlex | W3205588855 |
| Language | EN |
| Citations received | 2 |
| References cited | 65 |
Alcohol use disorder (AUD) has been related to aberrant functional connectivity (FC) in the salience network (SN), executive control network (ECN), and default mode network (DMN). However, there is a lack of comprehensive and simultaneous examination of these networks in patients with AUD and of their relation to potential anatomical changes. We aimed to comprehensively examine the alteration in FC in the three networks in AUD patients, and the correlation of the alteration with anatomical/structural changes (volume) in the neural areas implicated in these networks, by applying voxel-based morphometry (VBM) and region of interest-to-region of interest connectivity analysis simultaneously. In all, 22 patients with AUD and 22 healthy adults participated in the study and underwent T1 magnetic resonance imaging. Patients with AUD showed increased FCs within the DMN and SN networks, especially in terms of connectivity of the frontal areas and bilateral hippocampi. They also showed decreased FCs in the ECN. In addition, there was significant volume reduction in these areas (frontal areas and hippocampus). The increased FCs within the frontal areas or bilateral hippocampi showed a negative correlation with gray matter volume of these areas in AUD patients. Our findings add to the empirical evidence that the frontal lobe and hippocampi are critical areas that are vulnerable to functional and structural changes due to AUD
Alcohol · Alcohol use disorder · Biology · Default mode network · Frontal lobe · Functional magnetic resonance imaging · Magnetic resonance imaging · Neuroimaging · Radiology · Salience (neuroscience · Voxel-based morphometry · White matter · Functional Brain Connectivity Studies · Medicine · Memory and Neural Mechanisms · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychology
Saliency, switching, attention and control
Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
A fast diffeomorphic image registration algorithm
A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
Large-scale brain networks and psychopathology
Unified segmentation
Voxel-Based Morphometry—The Methods
Why Stress Is Bad for Your Brain
Global burden of disease attributable to mental and substance use disorders
Development of the Alcohol Use Disorders Identification Test (Audit)
| Citations per year | 0.5 |
|---|---|
| Citation span | 2022 - 2025 (4) |
| Highly cited | No |