A Deformation-Based Shape Study of the Corpus Callosum in First Episode Schizophrenia
Bibliographic Data
| ID | 15530373 |
|---|---|
| Authors | Wei‐Kai Huang (Southern University of Science and Technology), Weikai Huang, Minhua Chen (0000-0003-0513-1301, Southern University of Science and Technology), Guiwen Lyu (Shenzhen University), Xiaoying Tang (0000-0002-9610-0318, Southern University of Science and Technology, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 621515-621515 |
| Publication date | 2021-06-04 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.621515 |
| PMID | 34149469 |
| OpenAlex | W3169687697 |
| Language | EN |
| References cited | 57 |
Background: Previous first-episode schizophrenia (FES) studies have reported abnormalities in the volume and mid-sagittal size of the corpus callosum (CC), but findings have been inconsistent. Besides, the CC shape has rarely been analyzed in FES. Therefore, in this study, we investigated FES-related CC shape abnormalities using 198 participants [92 FES patients and 106 healthy controls (HCs)]. Methods: We conducted statistical shape analysis of the mid-sagittal CC curve in a large deformation diffeomorphic metric mapping framework. The CC was divided into the genu, body, and splenium (gCC, bCC, and sCC) to target the key CC sub-regions affected by the FES pathology. Gender effects have been investigated. Results: There were significant area differences between FES and HC in the entire CC and gCC but not in bCC nor sCC. In terms of the localized shape morphometrics, significant region-specific shape inward-deformations were detected in the superior portion of gCC and the anterosuperior portion of bCC in FES. These global area and local shape morphometric abnormalities were restricted to female FES but not male FES. Conclusions: gCC was significantly affected in the neuropathology of FES and this finding was specific to female FES. This study suggests that gCC may be a key sub-region that is vulnerable to the neuropathology of FES, specifically in female patients. The morphometrics of gCC may serve as novel and efficient biomarkers for screening female FES patients
Biology · Corpus callosum · Diffusion MRI · Disease · Magnetic resonance imaging · Morphometrics · Neuropathology · Pathology · Radiology · Splenium · Zoology · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Schizophrenia research and treatment · Anatomy
A Systematic Review of the Prevalence of Schizophrenia
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Rethinking schizophrenia
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
| Citation velocity | historical |
|---|---|
| Highly cited | No |