Identificación in silico del mimetismo molecular entre epitopes T de Neisseria meningitidis B y el proteoma humano
Bibliographic Data
| ID | 15533548 |
|---|---|
| Authors | Alexander Batista-Duharte (0000-0002-1875-0518, corresponding author), Bruno Téllez (Universidad de Oriente), Maybia Tamayo, Deivys Leandro Portuondo (0000-0003-2678-0431, Universidad de Ciencias Médicas de la Habana), Osmir Cabrera (Finlay Institute), Gustavo Sierra (0009-0009-2351-2758, Finlay Institute), Óliver Pérez (Finlay Institute) |
| Year | 2014 |
| Volume | 30 |
| Issue | 3 |
| Pages | 441-5 |
| Publication date | 2014-03-11 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Revista Peruana de Medicina Experimental y Salud Pública (JOURNAL) |
| Journal identifiers | ISSN: 1726-4634 • E-ISSN: 1726-4642 |
| Publisher | National Institute of Health of Peru (PUBLISHER • PE) |
| DOI | 10.17843/rpmesp.2013.303.281 |
| PMID | 24100820 |
| OpenAlex | W1849693199 |
| Language | ES |
| References cited | 1 |
The objective of the study was to determine the T-cell epitopes of four of the most frequent antigenic proteins of the outer membrane of Neisseria meningitidis B, and to identify the most relevant sites for molecular mimicry with T-cell epitopes in humans. In order to do so, an in silico study -a type of study that uses bioinformatic tools- was carried out using SWISS-PROT/TrEMBL, SYFPEITHI and FASTA databases, which helped to determine the protein sequences, CD4 and CD8 T-cell epitope prediction, as well as the molecular mimicry with humans, respectively. Molecular similarity was found in several human proteins present in different organs and tissues such as: liver, skin and epithelial tissues, brain, lymphatic system and testicles. Of these, those found in testicles were more similar, showing the highest frequency of mimetic sequences. This finding shed light on the success of N. meningitidis B to colonize human tissues and the failure of certain vaccines against this bacterium, and it even helps to explain possible autoimmune reactions associated with the infection or vaccination
Antigen · Bacteria · Biology · Epitope · Epitope mapping · Gene · In silico · Molecular mimicry · Neisseria meningitidis · Bacterial Infections and Vaccines · Glycosylation and Glycoproteins Research · vaccines and immunoinformatics approaches · Genetics · Microbiology · Molecular Biology · Virology
| Highly cited | No |
|---|