Polimorfismos del gen Arsénico 3 Metiltransferasa (As3MT) y la eficiencia urinaria del metabolismo del arsénico en una población del norte de México
Bibliographic Data
| ID | 15533756 |
|---|---|
| Authors | Francisco Javier García-Alvarado (0000-0002-3760-1876, Universidad Autónoma de Coahuila, corresponding author), Honorio Neri-Meléndez (Universidad Autónoma de Coahuila), Luz Pérez Armendáriz (Universidad Autónoma de Coahuila), Mario Rivera Guillen (Universidad Autónoma de Coahuila) |
| Year | 2018 |
| Volume | 35 |
| Issue | 1 |
| Pages | 72-72 |
| Publication date | 2018-03-23 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Revista Peruana de Medicina Experimental y Salud Pública (JOURNAL) |
| Journal identifiers | ISSN: 1726-4634 • E-ISSN: 1726-4642 |
| Publisher | National Institute of Health of Peru (PUBLISHER • PE) |
| DOI | 10.17843/rpmesp.2018.351.3565 |
| PMID | 29924282 |
| OpenAlex | W2794062216 |
| Language | ES |
| Citations received | 4 |
| References cited | 1 |
The aim of this study was to assess the relationship of the rs11191439 and rs3740393 polymorphisms of the Arsenite Methyltransferase (As3MT) gene with the arsenic urinary excretion profiles in a population in northern Mexico. A crosssectional study was conducted with 102 participants between the ages of 14 and 75 in Comarca Lagunera, Mexico. Speciation of the arsenic urinary metabolites was determined, and DNA was extracted; analysis and amplification of the polymorphisms was made by PCR in real time. A descriptive analysis was carried out and the differences in the urinary arsenic concentrations were assessed according to sex and genotype. The median concentration of arsenic in water was 82 μg/L; the levels of urinary excretion of dimethylarsinic acid (DMA) were higher in women than in the men. The carriers of the CC genetic variant of the As3MT (rs3740393) gene showed higher urinary concentrations of methylarsinic acid (p=0.01) and DMA (p=0.05)
Arsenic · Arsenite · Biology · Excretion · Population · Urinary system · Urine · Arsenic contamination and mitigation · Chemistry · Heavy Metal Exposure and Toxicity · Medicine · Selenium in Biological Systems · Endocrinology · Molecular Biology
A Theoretical–Methodological Model for the Study of Ancient Chromatic Technological Systems
Archaeometric Approach on Red Ocher of the Cabuza Phase (900–1200 Ad) From the Azapa Valley, Northern Chile
Chemical analyses of colors in the Cabuza phase ceramics (900–1200 CE), Azapa Valley, northern Chile
Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico
| Citations per year | 0.8 |
|---|---|
| Citation span | 2021 - 2026 (6) |
| Highly cited | No |