Polimorfismo genético de la apolipoproteína E en una población peruana
Bibliographic Data
| ID | 15534101 |
|---|---|
| Authors | Victoria Marca (National University of Engineering, corresponding author), Oscar Acosta (0000-0001-8156-6556, National University of San Marcos), Mario Cornejo‐Olivas (0000-0001-6313-5680, Instituto Neurológico de Colombia), Mario Cornejo-Olivas, Olimpio Ortega (Instituto Nacional de Salud), Diana Ramírez Huerta (0000-0001-5677-8688, National University of San Marcos), Doris Huerta, Pilar Mazzetti (0000-0002-4376-847X, National University of San Marcos) |
| Year | 2014 |
| Volume | 28 |
| Issue | 4 |
| Publication date | 2014-01-29 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Revista Peruana de Medicina Experimental y Salud Pública (JOURNAL) |
| Journal identifiers | ISSN: 1726-4634 • E-ISSN: 1726-4642 |
| Publisher | National Institute of Health of Peru (PUBLISHER • PE) |
| DOI | 10.17843/rpmesp.2011.284.420 |
| OpenAlex | W4245251709 |
| Language | ES |
| References cited | 9 |
Objectives. To determine the allelic and genotypic frequencies of the APOE gene in a sample of a population group in Peru. Materials and methods. Cross-sectional analytic study in 189 apparently healthy volunteers, workers of the Instituto Nacional de Ciencias Neurológicas in Lima, Perú, divided into 5 groups by birth department and two generations ancestry. Genomic DNA was amplified using PCR-RFLP. The resulting fragments were detected by 12 % polyacrylamide gel electrophoresis. Results. The Ɛ3 allele is the most frequent in all the groups (93.9 %), with low Ɛ4 (5 %) and Ɛ2 (1.1 %) allele frequencies. The analysis of heterozygosity (H) for each group displays intermediate diversity between 10 and 20%. Population genetic diversity (Ht) and diversity within populations (Hs) are 14.43 % and 14.31% respectively, suggesting genetic proximity between the studied groups for the ApoE polymorphism. Conclusions. Allele frequencies of the ApoE gene found show that allele Ɛ3 has one of the highest frequencies and Ɛ4 allele one of the lowest compared to other population groups in the world, with possible implications in the risk of neurological, cardiovascular and other diseases in our country
Allele · Allele frequency · Apolipoprotein E · Biology · Disease · Gene · Genetic diversity · genomic DNA · Genotype · Loss of heterozygosity · Polymorphism (computer science · Population · Restriction fragment length polymorphism · Lipoproteins and Cardiovascular Health · Medicine · Genetics · Internal Medicine
Analysis of Gene Diversity in Subdivided Populations
Performing the Exact Test of Hardy-Weinberg Proportion for Multiple Alleles
Molecular genetic analysis of the polymorphic apolipoprotein E in modern and ancient human DNA samples
High heterogeneity of Apolipoprotein E gene frequencies in South American Indians
Apoe distribution in world populations with new data from India and the UK
Worldwide allele frequencies of the human apolipoprotein E gene
| Highly cited | No |
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