Especificidad de la prueba intradérmica de Montenegro en pacientes infectados por Trypanosoma cruzi procedentes de diferentes regiones del Perú

In order to assess the specificity of the leishmanin skin test in Chagas disease patients without clinical history of leishmaniasis, present or former. A sample of 102 persons infected with Trypanosoma cruzi (14 acute cases with parasitological diagnosis and 88 chronic cases) through the demonstration of IgG antibodies by ELISA and indirect immunofluorescence (IIF) were evaluated with leishmanin soluble antigen which contained Leishmania (Viannia) peruviana concentration of 25-30 ug/mL. Only five people showed cutaneous hypersensitivity reaction to the application of the antigen between hours 48 and 72. The Leishmanin skin test evaluated was negative in 97 people infected with T. cruzi, thus specificity of 95.1% was achieved. In conclusion, the intradermal Montenegro test is a simple and effective diagnostic tool that also could be used to discriminate infections by Leishmania or T. cruzi, in Peruvian geographic areas where both parasites are present

Antigen · Biology · Cutaneous leishmaniasis · Disease · IIf · Indirect immunofluorescence · Leishmania · Leishmaniasis · Parasite hosting · Parasitic Disease · Pathology · Skin test · Trypanosoma cruzi · Medicine · Research on Leishmaniasis Studies · Synthesis and Biological Evaluation · Trypanosoma species research and implications · Immunology · Microbiology · Virology