Diversidad genómica de Escherichia coli uropatógena en aislados clínicos de seis países de Latinoamérica, 2018-2023

Datos Bibliográficos

ID15534722
AutoresFrancisco Luis Pacheco Caballero (Universidad Peruana Cayetano Heredia, autor de correspondencia), Francesca Caballero (0009-0001-7241-4136), Anne Martínez-Ventura (0009-0008-5271-4319, Universidad Peruana Cayetano Heredia), Diego Cuicapuza (0000-0002-5735-4614, Universidad Peruana Cayetano Heredia), Alexander Fajardo-Loyola (0000-0002-8162-1321, Instituto Nacional de Salud), Rosmery Gutiérrez Ajalcriña (0000-0001-8237-6092, Departamento de Epidemiología), Javier Soto Pastrana (0000-0001-9534-5746, Instituto Nacional de Salud del Niño), Percy Asmat-Marrufo (0000-0003-3377-6713, Private University of Trujillo), E Vera (0000-0002-9334-2661, Universidad Nacional de Tumbes), Henry Meza-Fernández (0000-0003-4973-7794, Hospital de Clínicas), Mario Chambi-Quispe (0000-0003-3303-2087, Universidad Privada San Carlos), Jimena Edith Pino-Dueñas (0000-0003-4563-5459, Universidad Andina del Cusco), Nicomedes Laura-Rivas (0000-0002-6413-3270, Universidad Nacional de Huancavelica), Alexander Briones (0000-0003-4849-6466, Universidad Particular de Iquitos), Pilar Elizabeth Diaz-Rengifo (0000-0002-0929-4602, Dirección Regional de Salud del Callao), Carlos Peralta (0000-0002-9605-8324, Amazon National University of Madre de Dios), Guillermo Salvatierra (0000-0002-6887-2599, Universidad Peruana Cayetano Heredia), Pablo Tsukayama (0000-0002-1669-2553, Universidad Peruana Cayetano Heredia), Pool Marcos-Carbajal (0000-0002-7741-0337, Universidad Peruana Cayetano Heredia)
Año2025
Volumen42
Número2
Páginas156-65
Fecha de publicación2025-06-19
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaRevista Peruana de Medicina Experimental y Salud Pública (JOURNAL)
Identificadores de la revistaISSN: 1726-4634 • E-ISSN: 1726-4642
EditorialNational Institute of Health of Peru (PUBLISHER • PE)
DOI10.17843/rpmesp.2025.422.14299
PMID40900482
OpenAlexW4413970267
IdiomaES

Motivation for the study. To contribute to the genomic surveillance of UPEC in clinical samples from Latin America, in response to the growing public health problem represented by UTIs and their resistance to antimicrobials. Main findings. Our study revealed a high frequency of high-risk clones, such as ST131 and ST1193. Critical mutations were identified in genes associated with resistance to multiple antibiotics, including fluoroquinolones, beta-lactams, and fosfomycin. Implications. Our results highlight the urgent need to strengthen UPEC surveillance in Latin America. Tracking resistant strains and implementing measures to limit their spread is crucial and has a significant impact on the effectiveness of available treatments

Biology · Diversity (politics · Environmental health · Escherichia coli · Evolutionary biology · Gene · Genetic diversity · Latin Americans · Political science · Sociology · Anthropology · Escherichia coli research studies · Medicine · Urinary Tract Infections Management · Genetics · Microbiology