Serum 25 hydroxyvitamin D status in 6‐month‐old infants in Guangzhou, China

A paired longitudinal follow up study

Bibliographic Data

ID15535962
AuthorsJing Wang (0000-0002-7594-8539, Guangzhou Women and Children Medical Center), Joy Yue Zhang (Guangzhou Medical University), Wei Ru (0000-0002-0110-6531, Guangzhou Women and Children Medical Center), Ru Wei (Department of Children Health Care, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China), Shun-Ping Hu (Guangzhou Women and Children Medical Center), Shunping Hu (Department of Obstetrics, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China), Tao Lin (0000-0001-5095-3908, Guangzhou Women and Children Medical Center), Gendie E Lash (0000-0002-3606-1361, Guangzhou Medical University, corresponding author), Meizhen Tan (Guangzhou Women and Children Medical Center, corresponding author)
Year2020
Volume16
Issue2
Pagese12924-e12924
Publication date2020-01-22
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueMaternal and Child Nutrition (JOURNAL)
Journal identifiersISSN: 1740-8695 • E-ISSN: 1740-8709
PublisherWiley (PUBLISHER • GB)
DOI10.1111/mcn.12924
PMID31970860
OpenAlexW3002805613
LanguageEN
Citations received1
References cited21

To assess the vitamin D status in healthy 6-month-old infants, as well as vitamin D supplementation and feeding patterns in Guangzhou, China, serum 25-hydroxyvitamin D (25OHD) concentrations of 202 infants were measured at birth (cord blood) and at 6 months of age in Guangzhou, China. Questionnaires acquiring demographic characteristics, maternal and infantile vitamin D supplementation during pregnancy and first 6 months after birth, and feeding patterns during the first 6 months were completed by participating mothers. Physical examinations and blood sampling were carried out among infants at 6 months of age. The majority of infants (93.6%) were supplemented with vitamin D during the first 6 months of life on a voluntary basis. The M ± SD of cord serum 25OHD concentration was 46.2 ± 16.4 nmol/L, whereas the M ± SD of 25OHD concentration at 6 months was 82.9 ± 24.9 nmol/L. Serum 25OHD concentrations 75 nmol/L at birth, whereas the majority of infants (n = 131, 64.9%) had concentrations >75 nmol/L at 6 months. The main predictors of 25OHD levels at 6 months included season, vitamin D supplementation, parental education level, and feeding patterns. To conclude, serum 25OHD concentrations were low at birth in a southern Chinese population, and infantile supplementation is an effective way to improve 25OHD status. Exclusively breastfed infants might need greater vitamin D supplementation, and individualized vitamin D supplementation plans might be needed

Cord blood · Population · Vitamin · Vitamin D and neurology · vitamin D deficiency · Breastfeeding Practices and Influences · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Vitamin D Research Studies · Internal Medicine · Pediatrics · Physiology