Suboptimal maternal and cord plasma pyridoxal 5′ phosphate concentrations are uncommon in a cohort of Canadian pregnant women and newborn infants

Vitamin B 6 is important in fetal development, but little is known of the vitamin B 6 status of pregnant women and newborns in North America and potential modifying factors. This prospective study determined maternal and cord plasma concentrations of pyridoxal 5' phosphate (PLP; an indicator of vitamin B 6 status) in a convenience sample of 368 Canadian pregnant women and their newborns. The association of maternal intake of vitamin B 6 and fetal genetic variants with cord plasma PLP and homocysteine concentrations was also examined. Dietary and supplemental intakes of vitamin B 6 were assessed in early and mid to late pregnancy. PLP concentrations were measured in maternal plasma in early pregnancy and at delivery, and in cord plasma. Six fetal variants of the MTHFR and CβS genes were assessed for their association with cord plasma PLP and homocysteine concentrations. Geometric mean (95% CI) PLP concentrations were 107 (98, 116) nmol/L in early pregnancy and 58 (53, 62) nmol/L at delivery, respectively, and 296 (275, 319) nmol/L in cord blood (p 6 intake of at least the recommended dietary allowance had PLP concentrations >20 nmol/L. Fetal genetic variants were not associated with cord PLP and homocysteine concentrations. Vitamin B 6 deficiency is uncommon in a cohort of Canadian pregnant women due largely to prevalent vitamin B 6 supplement use

Biology · Cohort · Cord · Cord blood · Enzyme · Fetus · Genotype · Homocysteine · Methylenetetrahydrofolate reductase · Obstetrics · Phosphate · Pregnancy · Prospective cohort study · Pyridoxal · Pyridoxal phosphate · Umbilical cord · Vitamin · Folate and B Vitamins Research · Medicine · Metabolism and Genetic Disorders · Prenatal Substance Exposure Effects · Biochemistry · Endocrinology · Immunology · Internal Medicine · Physiology · Surgery

• Suboptimal maternal and cord plasma pyridoxal 5′ phosphate concentrations are uncommon in a cohort of Canadian pregnant women and newborn infants

  Open Access•Lesley Plumptre, Shannon P Masih et al.•Maternal and Child Nutrition•2017

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• Regression to the mean

  Adrian Barnett, A G Barnett•International Journal of…•2004

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• Suboptimal maternal and cord plasma pyridoxal 5′ phosphate concentrations are uncommon in a cohort of Canadian pregnant women and newborn infants

  Open Access•Lesley Plumptre, Shannon P Masih et al.•Maternal and Child Nutrition•2017

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• Validity and reliability of the Block98 food-frequency questionnaire in a sample of Canadian women

  Open Access•Beatrice A Boucher, Beatrice Boucher et al.•Public Health Nutrition•2006

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