Daily Complementary Feeding With Eggs Improves Fibroblast Growth Factor 21 in Infants
Bibliographic Data
| ID | 15536276 |
|---|---|
| Authors | Regina Nakiranda (0000-0001-8057-2751, North-West University, corresponding author), Linda Malan (0000-0001-6609-0238, North-West University), Hannah Ricci (0000-0003-0656-503X, North-West University), Herculina S Kruger (0000-0002-5365-1777, North-West University), Arista Nienaber (0000-0002-1013-6740, North-West University), Marina Visser (0000-0002-6173-0651, North-West University), Cristian Ricci (0000-0003-4113-8682, North-West University), Mieke Faber (0000-0002-8878-254X, South African Medical Research Council), Cornelius M Smuts (0000-0003-4829-0054, North-West University) |
| Year | 2024 |
| Volume | 21 |
| Issue | 2 |
| Pages | e13782-e13782 |
| Publication date | 2024-12-09 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Maternal and Child Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1740-8695 • E-ISSN: 1740-8709 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1111/mcn.13782 |
| PMID | 39648796 |
| OpenAlex | W4405197998 |
| Language | EN |
| Citations received | 1 |
| References cited | 6 |
This secondary analysis of the Eggcel-growth study investigated the effect of daily egg intake for 6 months in infants aged 6-9 months on environmental enteric dysfunction (EED) biomarkers and the association of EED markers with growth faltering. A randomised controlled trial was conducted in Jouberton, South Africa, among 500 infants randomly assigned equally to either an intervention group receiving a daily chicken egg or a control group. Both groups were followed up for 6 months. Data on infant and maternal sociodemographic information and anthropometric status of infants were collected. EED and inflammatory markers were analysed using Q-Plex Human EED (11-Plex) assay. There was a significant reduction in fibroblast growth factor 21 (FGF21) concentration in the intervention group (B = -0.132; 95% CI -0.255, -0.010; p = 0.035). Baseline, insulin-like growth factor 1 (IGF-1) was positively associated with endpoint length-for-age z-score (LAZ), weight-for-age z-score (WAZ) and weight-for-length z-score (WLZ) and there was an inverse relationship between baseline FGF21 and intestinal fatty acid-binding protein (I-FABP) with endpoint growth indicators. Baseline IGF-1 was positively associated with reduced odds of wasting, stunting and being underweight (p < 0.001) and baseline FGF21 was associated with increased odds of stunting (p = 0.002), wasting (p = 0.031) and being underweight (p = 0.035). There was a 20% increased odds of stunting with baseline I-FABP (p = 0.045) and a 30% increased odds of being underweight with baseline soluble CD14 (p = 0.039). Complementary feeding with eggs decreased growth hormone resistance (reduced FGF21 levels); however, FGF21 and I-FABP levels were linked to increased growth faltering. Trial Registration: ClinicalTrials.gov: NCT05168085
Anthropometry · Body mass index · Clinical endpoint · Logistic regression · Odds · Odds ratio · Overweight · Randomized controlled trial · Standard score · Underweight · Wasting · Child Nutrition and Feeding Issues · Congenital Diaphragmatic Hernia Studies · Medicine · Neonatal Respiratory Health Research · Internal Medicine · Pediatrics
| Citations per year | 1 |
|---|---|
| Citation span | 2025 - 2025 (1) |
| Highly cited | No |