Association analysis between CD45 lymphocyte counts and the risk of major depressive disorder
A cross-sectional study
Bibliographic Data
| ID | 15699717 |
|---|---|
| Authors | Jiaxin Tian (0000-0001-9269-3462, Ningbo University), J Feng (Ningbo University), Guoping Li (0000-0002-3745-7480, Zhejiang Medicine (China)), Yanqing Xue (Ningbo University), Yanbin Hou (Ningbo First Hospital), Danjuan Wu (Ningbo First Hospital), Sheng Nie (0000-0002-8267-7909, Ningbo University), Yunxin Ji (0000-0001-6112-3440, Ningbo First Hospital), Liemin Ruan (Ningbo University), Zhongze Lou (0000-0002-1757-9368, Zhejiang University of Science and Technology, corresponding author) |
| Year | 2025 |
| Volume | 13 |
| Issue | 1 |
| Pages | 1341-1341 |
| Publication date | 2025-12-08 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | BMC Psychology (JOURNAL) |
| Journal identifiers | ISSN: 2050-7283 • E-ISSN: 2050-7283 |
| Publisher | BioMed Central (PUBLISHER • GB) |
| DOI | 10.1186/s40359-025-03681-1 |
| PMID | 41361318 |
| OpenAlex | W4417112951 |
| Language | EN |
| References cited | 5 |
The onset and progression of major depression have been closely linked to the human inflammatory immune system, with T cells playing a crucial role in immune function. Recent studies have highlighted significant associations between changes in T cell-related subpopulations and the onset and progression of major depression. So, the aim of this study was to investigate the relationship between T lymphocyte subset alterations and major depressive disorder (MDD). First, a total of 108 participants were included in this study and were categorized according to the International Classification of Diseases Tenth Revision diagnostic criteria (ICD-10) into four groups: the healthy group (n = 30), the mild depression group (n = 26), the moderate depression group (n = 31), and the major depression group (n = 21). Venous blood samples were collected from all participants, and T cell-related subpopulation markers were analyzed through flow cytometry. Statistical analysis revealed a close link between the CD45 + lymphocyte counts and the risk of major depression. Higher levels of CD45 + lymphocyte counts were correlated with an increased likelihood of developing major depression. In conclusion, this study identified T cell-related subpopulations, particularly CD45 + lymphocyte counts, which are closely associated with the major depression, possibly offering a new avenue for the auxiliary diagnosis of the major depressive disorder
Depression (economics · Immune system · Lymphocyte · Lymphocyte subsets · Major depressive disorder · Psychoneuroimmunology · T lymphocyte · Stress Responses and Cortisol · Treatment of Major Depression · Tryptophan and brain disorders
| Highly cited | No |
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