Diagnostic Performance of Sars-CoV-2 Rapid Antigen Test in a Large, German Cohort
Bibliographic Data
| ID | 15712423 |
|---|---|
| Authors | Olivier Mboma (Witten/Herdecke University), Elmar Rieke (Witten/Herdecke University), Parviz Ahmad‐Nejad (0000-0001-9439-7317, Witten/Herdecke University), Parviz Ahmad-Nejad (Institute for Medical Laboratory Diagnostics, Center for Clinical and Translational Research (CCTR), Helios University Hospital Wuppertal, Witten/Herdecke University, 42283 Wuppertal, Germany), Stefan Wirth (0000-0003-4576-3987, Helios Universitätsklinikum Wuppertal), Malik Aydin (0000-0002-1340-9687, Helios Universitätsklinikum Wuppertal, corresponding author) |
| Year | 2021 |
| Volume | 8 |
| Issue | 8 |
| Pages | 682-682 |
| Publication date | 2021-08-08 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children8080682 |
| PMID | 34438573 |
| OpenAlex | W3188082606 |
| Language | EN |
| References cited | 39 |
We assessed the performance of a rapid antigen test (RAT) in everyday clinical practice. Between 1 November 2020 until 1 April 2021 all in-patients at the Helios University Hospital Wuppertal, Germany, as well as the accompanying relatives at the Children's Hospital received a SARS-CoV-2 RAT and a SARS-CoV-2 RT-PCR prior to admission. Out of 3686 patients, 22 (0.6%) subjects were tested positive by RT-PCR and RAT, and 3591 (97.4%) were negative by both methods, showing discordant results: RT-PCR+/RAT- in 58 (1.6%) and RT-PCR-/RAT+ in 15 patients (0.4%). Overall sensitivity and specificity of RAT was 27.5% (95%CI 18.1-38.6%) and 99.6% (95%CI 99.3-99.8%), respectively. The sensitivity was slightly higher in adults (30.4%, 95%CI 18.8-90.9%) than in pediatric subjects (20.8%, 95%CI 7.1-42.2%). False negative RAT had a statistically higher Ct-value ( p < 0.001) compared to true positive values, and overall sensitivity increased to 80% [59.3-93.2%] with Ct value < 30. While the sensitivity of the RAT was poor compared with the RT-PCR, the specificity was excellent. However, the sensitivity increased with lower Ct value, and with the right anamnesis the RAT can be a quick and easy approach to distinguish people who are infectious with SARS-CoV-2 from noninfectious people, enabling appropriate triage in clinical practice while waiting for the RT-PCR result
Anamnesis · Clinical Practice · Cohort · Coronavirus disease 2019 (COVID-19 · Disease · Infectious disease (medical specialty · Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 · Triage · COVID-19 Clinical Research Studies · Medicine · SARS-CoV-2 and COVID-19 Research · SARS-CoV-2 detection and testing · Emergency Medicine · Gastroenterology · Internal Medicine
| Highly cited | No |
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