The Risk of Nonsteroidal Anti-Inflammatory Drugs in Pediatric Medicine
Listen Carefully to Children with Pain
Bibliographic Data
| ID | 15712448 |
|---|---|
| Authors | Olivier Mboma (Witten/Herdecke University), Stefan Wirth (0000-0003-4576-3987, Witten/Herdecke University), Malik Aydin (0000-0002-1340-9687, Witten/Herdecke University, corresponding author) |
| Year | 2021 |
| Volume | 8 |
| Issue | 11 |
| Pages | 1048-1048 |
| Publication date | 2021-11-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children8111048 |
| PMID | 34828761 |
| OpenAlex | W3213748009 |
| Language | EN |
| Citations received | 1 |
| References cited | 22 |
Over the last decades, the use of over-the-counter analgesics in the general population has increased in Germany. Ibuprofen is one of the most commonly used nonsteroidal anti-inflammatory drug (NSAID) and is frequently prescribed to children as an analgesic and/or antipyretic. Besides having a well-established safety and efficacy profile when used in appropriate doses, cases of NSAID-induced acute kidney injury (AKI) have been described in the pediatric population, particularly in the context of dehydration and in combination with other drugs. The ingestion of more than 400 mg/kg is associated with severe or life-threatening toxicity. This report is about two previously healthy adolescents, who developed AKI after taking high daily dose of ibuprofen as a pain reliever without any appropriate medical supervision. With these case reports, in addition to the side effect profiles of this analgesic, we would also like to present a certain therapeutic recommendation that we applied in these patients, and furthermore appeal to pediatricians to strictly set the indications for ibuprofen intake
Analgesic · Anesthesia · Antipyretic · Context (archaeology · Drug · Ibuprofen · Intensive care medicine · Nonsteroidal · Population · Drug-Induced Hepatotoxicity and Protection · Medicine · Nephrotoxicity and Medicinal Plants · Poisoning and overdose treatments · Pharmacology
| Citations per year | 1 |
|---|---|
| Citation span | 2026 - 2026 (1) |
| Highly cited | No |