Is the Leptin/Adiponectin Ratio a Better Diagnostic Biomarker for Insulin Resistance than Leptin or Adiponectin Alone in Adolescents
Bibliographic Data
| ID | 15713286 |
|---|---|
| Authors | César Agostinis‐sobrinho (0000-0001-9104-9042, Klaipėda University, corresponding author), Sofia Emanuelle de Castro Ferreira Vicente (0000-0002-6913-7879, Klaipėda University), Sigute Norkiene (0000-0002-3231-5168, Klaipėda University), Alona Rauckienė-Michaelsson (0000-0003-0337-8335, Klaipėda University), Justina Kievišienė (0000-0002-6524-9910, Klaipėda University), Viney Prakash Dubey (0000-0001-6959-1310, Klaipėda University), Artūras Razbadauskas (0000-0002-6524-5354, Klaipėda University), Luís Lopes (0000-0001-6680-0893, Universidade do Porto), Rute Santos (0000-0002-7604-5753, Universidade do Porto) |
| Year | 2022 |
| Volume | 9 |
| Issue | 8 |
| Pages | 1193-1193 |
| Publication date | 2022-08-09 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children9081193 |
| PMID | 36010082 |
| OpenAlex | W4293681095 |
| Language | EN |
| References cited | 8 |
Background: Recently, the leptin/adiponectin (L/A) ratio has been suggested as a novel predictor of cardio-metabolic and other chronic diseases. Aim: To evaluate the ability of leptin (L), adiponectin (A), and the L/A ratio in identifying high risk of insulin resistance IR in adolescents, adjusted by cardiorespiratory fitness, adherence to the Mediterranean diet, and body fat percentage. Subjects and methods: This is a cross-sectional analysis with 529 adolescents aged 12−18 years-old. Blood samples were taken to analyze glucose, insulin, leptin, and adiponectin levels. IR (homeostasis model assessment of insulin resistance (HOMA-IR) was estimated from fasting serum insulin and glucose). Results: Adiponectin, leptin, and L/A ratio were accurate to predict IR among adolescents. The optimal L/A cut-off value to indicate risk of IR development was >0.35 in boys and >0.97 in girls. Logistic analyses showed that the suggested cut-off points for adiponectin (girls: OR: 2.87 (1.26−6.53); p = 0.012); leptin (boys: OR: 5.23 (1.16−7.14) p = 0.006; girls: OR: 2.99 (1.10−8.09) p = 0.031), and the L/A ratio (boys: OR: 8.38 (2.6−26.8) p < 0.001; girls: OR: 6.1 (2.1−17.0) p < 0.001), were significant predictors of IR, after adjustments for age, pubertal stage, adherence to the Mediterranean diet, cardiorespiratory fitness, and body fat percentage. Conclusion: Leptin and L/A ratio were associated with IR risk, after adjustments for confounders in both sexes and adiponectin in girls. The L/A ratio seems to have a higher diagnostic accuracy to identify IR risk than adiponectin or leptin, in both sexes
Adipokine · Adiponectin · Biology · Biomarker · Cardiorespiratory fitness · Confounding · Homeostatic model assessment · Insulin · Insulin resistance · Leptin · Obesity · Adipokines, Inflammation, and Metabolic Diseases · Medicine · Obesity, Physical Activity, Diet · Regulation of Appetite and Obesity · Endocrinology · Internal Medicine
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Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.
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| Highly cited | No |
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