Depression and Anxiety in Pediatric Patients with Beckwith–Wiedemann Syndrome

A Pilot Study

Bibliographic Data

ID15713466
AuthorsGrazia D’Onofrio (0000-0002-5905-6063, Casa Sollievo della Sofferenza, corresponding author), Annalisa Mastromatteo (Istituti di Ricovero e Cura a Carattere Scientifico), Andrea Di Francesco (0000-0001-6867-8203, Azienda Socio Sanitaria Territoriale Lariana), Antonio Izzi (0000-0001-6776-5655, Casa Sollievo della Sofferenza), Vincenzo Marchello (Istituti di Ricovero e Cura a Carattere Scientifico), Aldo Manuali (Casa Sollievo della Sofferenza), Andreaserena Recchia (0000-0002-0376-7464, Istituti di Ricovero e Cura a Carattere Scientifico), Maria Pia Tonti (0000-0002-1734-2213, Istituti di Ricovero e Cura a Carattere Scientifico), Maria Lazzarina Russo (Istituti di Ricovero e Cura a Carattere Scientifico), Maria Pia Affatato (Istituti di Ricovero e Cura a Carattere Scientifico), Alessandra Rossato (Istituti di Ricovero e Cura a Carattere Scientifico), Cecilia Giuntoli (Istituti di Ricovero e Cura a Carattere Scientifico), Nicola Palladino (0000-0001-5472-5814, Casa Sollievo della Sofferenza), Michele Germano (Istituti di Ricovero e Cura a Carattere Scientifico), Maria Pastore (0000-0001-6666-7826, Istituti di Ricovero e Cura a Carattere Scientifico), Maria Rosa Pastore (Complex Unit of Pediatrics, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy), Lazzaro Cassano (Istituti di Ricovero e Cura a Carattere Scientifico)
Year2024
Volume11
Issue3
Pages342-342
Publication date2024-03-13
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children11030342
PMID38539377
OpenAlexW4392745995
LanguageEN
References cited19

The study's aim was to determine the prevalence of depression and anxiety in children with Beckwith-Wiedemann syndrome (BWS) and their effects on social relationships and family acceptance. The Pediatric Symptom Checklist-35 items (PSC-35), Screen for Child Anxiety Related Emotional Disorders (SCARED), and the Vineland Adaptive Behavior Scale Second Edition (VABS-II) were administered to the children. The parental Acceptance Rejection/Control Questionnaire (PARQ/Control) and Zarit Burden Inventory (ZBI) were administered to parents. In total, 6 patients and 10 parents were included. Patients showed a significant presence of internalizing behavior in PSC-35 (mean, 7.66 ± 3.67), anxiety symptoms (SCARED: mean, 46.33 ± 17.50) and socialization difficulties (mean, 90.83 ± 10.09). Parents reported a perceived good acceptance (mean, 56.33 ± 1.03) and a moderate control (mean, 24.17 ± 1.83), but the burden level was ranked moderate to severe (mean, 59.33 ± 16.78). It was found that the severity of the burden level reported by parents was related to internalizing behavior (OR = 2.000; 95% CI = 0.479-3.521; p = 0.022) and anxiety symptoms (SCARED total score: OR = 3.000; 95% CI = 1.479-4.521; p = 0.005) of children. During psychological counseling in the context of BWS treatment, it is important to identify specific resources that can support patients and families in dealing with stress and identify any critical areas that could hinder the adaptation process

Anxiety · Checklist · Context (archaeology · Depression (economics · Distress · Psychiatry · Adolescent and Pediatric Healthcare · Clinical Psychology · Family Support in Illness · Genetic Syndromes and Imprinting · Medicine · Psychology

Tools

Open DOIOpen Access