The Association Between Perinatal Pharmacologic Treatments and Spontaneous Intestinal Perforation in Extremely Preterm Infants
A Propensity Score Matching Study
Bibliographic Data
| ID | 15713632 |
|---|---|
| Authors | Wei Cheng (0000-0003-1118-1743, Chang Gung University), Wei-Hsin Cheng (Chang Gung University), Ly Tu (0000-0003-2336-5099, Chang Gung University), Lo-Hsuan Tu (Chang Gung University), Ming‐Chou Chiang (0000-0003-1109-0665, Chang Gung University), Ming-Chou Chiang (Chang Gung University), Yu-Ning Chen (0009-0000-2777-1903, Chang Gung University), Wei-Hung Wu (Chang Gung University), Kai‐Hsiang Hsu (0000-0003-2852-6322, Chang Gung University, corresponding author) |
| Year | 2025 |
| Volume | 12 |
| Issue | 2 |
| Pages | 142-142 |
| Publication date | 2025-01-27 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children12020142 |
| PMID | 40003244 |
| OpenAlex | W4406842357 |
| Language | EN |
| Citations received | 1 |
| References cited | 23 |
Background : The impact of perinatal pharmacologic agents on spontaneous intestinal perforation (SIP) in extremely low-birthweight (ELBW, Methods : We retrospectively reviewed ELBW infants in our unit between 2014 and 2023 to identify SIP cases. Confirmed through medical notes, surgical consultation, and author review, each SIP case was matched at a 1:3 ratio using propensity scores on factors including the gestational age (GA), birthweight, gender, and birth year. Pharmacologic agents commonly given antenatally and postnatally were analyzed. Only medications that were started 24 h before the onset of SIP or the corresponding age (PSM-controls) were included. Results : A total of 858 ELBW infants were reviewed, 28 SIP cases (GA 25.3 ± 2.1 weeks, BW 735 ± 167 g) were identified, and 84 PSM-controls were matched. The SIP cases received hydrocortisone (25% (7/28) vs. 9.5% (8/84), p = 0.037) and combined inotropic agents (17.9% (5/28) vs. 2.4% (2/84), p = 0.020) to a significantly greater extent. No differences were observed in the use of other medications. In logistic regression, the use of hydrocortisone and combined inotropes remained independent risks for SIP, with ORs (95% CIs) of 3.4 (1.1-10.9) and 2.1 (1.2-3.8), respectively. Conclusions : This first PSM-based study supported postnatal hydrocortisone and combined inotrope use as independent risks for SIP in ELBW infants. Clinicians should be aware of these risks and remain vigilant for SIP when administering hydrocortisone and inotropes
Cohort · Gestational age · Inotrope · Logistic regression · Perforation · Pregnancy · Propensity score matching · Retrospective cohort study · Infant Development and Preterm Care · Infant Nutrition and Health · Medicine · Neonatal Respiratory Health Research · Internal Medicine · Pediatrics
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |