Temporal Shifts in Pathogen Profiles Due to the Covid-19 Pandemic in a Romanian Pediatric Tertiary Hospital

Bibliographic Data

ID15713649
AuthorsDan Dumitru Vulcănescu (0000-0003-1046-7272, Victor Babeș University of Medicine and Pharmacy Timișoara), Iulia Cristina Bagiu (0000-0003-3099-8249, Victor Babeș University of Medicine and Pharmacy Timișoara), Monica Suşan (0000-0002-6923-9146, Victor Babeș University of Medicine and Pharmacy Timișoara), Virgiliu Bogdan Sorop (Victor Babeș University of Medicine and Pharmacy Timișoara), Octavia Oana Harich (Victor Babeș University of Medicine and Pharmacy Timișoara), Octavia Harich (Victor Babeș University of Medicine and Pharmacy Timișoara), Andrada Oprişoni (Victor Babeș University of Medicine and Pharmacy Timișoara), Radu Galiș (0000-0002-4165-8816, Poznan University of Medical Sciences, corresponding author), Florin George Horhat (0000-0001-6133-0204, Romanian Academy)
Year2025
Volume12
Issue9
Pages1258-1258
Publication date2025-09-18
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children12091258
PMID41007123
OpenAlexW4414325941
LanguageEN
References cited47

Background : The COVID-19 pandemic disrupted pediatric healthcare systems globally, altering infection dynamics, hospital admissions, and antimicrobial practices. This study aimed to evaluate temporal shifts in patient demographics, clinical aspects, and microbial pathogen profiles in a tertiary pediatric hospital in Western Romania, spanning pre-pandemic (2019), pandemic (2021), and post-pandemic (2023) periods. Methods : A retrospective observational study was conducted at the "Louis Țurcanu" Emergency Children's Hospital, Timișoara. Pediatric patients ( 2 tests, incidence rate ratios (IRR), and non-parametric statistical methods. Results : A total of 3530 patients and 6885 samples were analyzed. Pediatric admissions declined by nearly 50% during the pandemic. The Outpatient and Emergency department observed a decrease in cases, while the ICU and surgical ward cases increased proportionally. Nasal and pharyngeal samples declined during the pandemic, while catheter, blood, and conjunctival samples rose. The study identified a significant shift in pathogen prevalence, with Escherichia coli and Staphylococcus aureus as the most frequent isolates. ICU patients showed increased rates of Pseudomonas aeruginosa , Candida albicans , and Klebsiella pneumoniae . Group A Streptococcus resurged post-pandemic after a decline in 2021. Conclusions : The pandemic significantly impacted pediatric infection profiles, hospital service utilization, and sample collection patterns. Strengthening infection surveillance, ensuring consistent reporting standards, and adapting pediatric care to future crises are critical for improving child health outcomes

Emergency department · Incidence (geometry · Observational study · Pandemic · Pathogen · Pediatric hospital · Retrospective cohort study · Tertiary care · COVID-19 epidemiological studies · Pneumonia and Respiratory Infections · Respiratory viral infections research

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